Revista de la Facultad de Medicina Humana <p><span id="result_box" class="" lang="en" tabindex="-1"><span class=""><span style="vertical-align: inherit;"><span style="vertical-align: inherit;">The "Revista de la Facultad de Medicina Humana" of the Ricardo Palma University (Rev. Fac. Med. Hum.) is the organ of scientific diffusion of the faculty and a publication for the medical community as a whole. This comunity includes students, graduates, academics, researchers and national and international institutions. It covers current issues, with original and unpublished articles, related to the various specialties of the biomedical and Public Health area.</span></span></span></span></p> Universidad Ricardo Palma en-US Revista de la Facultad de Medicina Humana 1814-5469 Case report: Gastrointestinal stromaal tumor (GIST) in the jejunum <p class="p1">Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms that represent less than 3% of gastrointestinal neoplasms, with an incidence of 1 to 2 cases per hundred thousand inhabitants. It originates more frequently in the stomach and small intestine and is characterized by the expression of the tyrosine kinase growth factor receptor, CD117. Therefore, its diagnosis requires an immunohischemical study to rule it out from other mesenchymal tumors. However, enteroscopic imaging and analysis of the biopsy may suggest a preoperative diagnosis of probable GIST.</p> <p class="p1">The case of a 62-year-old woman with rectorrhagia and recurrent anemia caused by mid-intestinal bleeding observed by capsule endoscopy is reported. Enteroscopy revealed a subepithelial ulcerated lesion in the proximal jejunum, and a biopsy was taken, the anatomopathological study of which suggested a gastrointestinal stromal tumor. The biopsy sample subjected to immunohistochemical studies confirms the suspicion of a cKit/CD117-positive GIST tumor. Surgical resection of the tumor with dimensions 4.2x3 cm is performed. After surgery, the patient was stable and under clinical follow-up until she was discharged. Clinical finding</p> Jose Mantilla Alessandra Canelo Alejandro Llanos-Salirrosas Elver López Lucero Mejía Sharon Polo Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-26 2023-01-26 23 1 10.25176/RFMH.v23i1.5309 Small bowel arteriovenous malformation as a cause of dark gastrointestinal bleeding: Two instructional cases <p><strong>ABSTRACT</strong></p> <p><strong>Introduction:</strong> Digestive bleeding can put patients’ lives at risk, even more so when the origin is not located in routine upper and lower endoscopy. The small intestine is the largest portion of the digestive tract and being a source of bleeding means a diagnostic and therapeutic medical challenge. <strong>Clinical case:</strong> We presented cases of two female patients, 53 and 60 years old, who develop digestive bleeding, locating its origin in the small bowel and undergoing surgical removal of the affected intestinal segment. The anatomopathological study finds malformed arteries and veins that communicate without an intermediate capillary bed. The diagnosis was arteriovenous malformation, a rare entity in the small bowel. Both cases are reviewed with emphasis on the histopathological criteria and their clinical correlation.</p> <p><strong>Keywords:</strong> Arteriovenous malformation, small bowel, obscure digestive bleeding.</p> Eugenio Américo Palomino Portilla María del Pilar Quiñones Ávila Isaira Giovanna Torpoco Baquerizo María Angélica Medrano Huallanca Katia Sofía Palomino Aguilar Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-26 2023-01-26 23 1 Seawater products for nasal lavages. Comparison and literature review <p><strong>Introduction. </strong>There is a wide range of seawater products for nasal lavages. Their efficacy and superiority over conventional saline solutions are not well established.</p> <p><strong>Objectives. </strong>To analyse the best-selling seawater products, as well as reviewing the most recent literature regarding nasal lavages.</p> <p><strong>Methods. </strong>Comparative study of composition, administration mode, age indicated for its use, price and bibliography provided on the web of the seawater products usually available in pharmacies. Analysis of the bibliography provided and review of the scientific evidence regarding nasal lavages with saline solutions or seawater.</p> <p><strong>Results. </strong>44 products from 11 manufacturers were analysed. The concentration of sodium chloride varies from 0.9% to 2.5%. The most frequent mode of application is spray. The addition of plants, salts and other components is common. Only two brands provide bibliographic references on their website. According to the literature reviewed, both saline solutions and seawater seem especially useful in the treatment of upper respiratory tract infections and allergic rhinitis.</p> <p><strong>Conclusions. </strong>There is no solid scientific evidence regarding the benefits of nasal lavages. With the current evidence it is not possible to recommend seawater over conventional saline or to establish the optimal concentration of the solution or the most convenient mode of administration. The addition of elements to seawater solutions is not justified enough.</p> Irene López Barea Luis Molini Cabrera Manuel Enrique García Falcón Cristóbal Coronel Rodríguez Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-27 2023-01-27 23 1 10.25176/RFMH.v23i1.5085 Pharmacological efficacy of Aloe vera in wound healing: a narrative review <p>Aloe Vera has different therapeutic effects, including wound healing. The aim of this review is to determine the potential efficacy of topical use of Aloe Vera in skin wound healing. A bibliographic search of preclinical and clinical studies from 1999 to 2020 was carried out, which included the therapeutic use of Aloe vera in the healing of: burns, surgical wounds, lactation disorders, anal fissure and anal fistula; in the databases of the VHL Regional Portal, PubMed and Google Scholar. It was obtained that the topical administration of Aloe vera was effective in the healing of the mentioned wounds by mainly increasing epithelialization and collagen content. In conclusion, the properties and pharmacological presentation, chemical components and the effectiveness of Aloe vera to reduce the time of wound healing, make this plant a great therapeutic alternative.</p> <p><strong>Key words: </strong>Aloe vera, wound healing, burns, surgical wounds, fissure in ano. (source: MeSH NLM)</p> Sandra Viviana Aparicio Salcedo Brian Steven Carranza Aldana Sayuri Anayca Chávez Salas Leslie Solanth Quispe Tinco Carlos Abel Palomino Zevallos Ariana Nicole Peralta Medina Juana Mónica Robles Esquerre Copyright (c) 1970 Revista de la Facultad de Medicina Humana 2023-01-27 2023-01-27 23 1 10.25176/RFMH.v23i1.4341 Depression, anxiety and stress according to belonging to a religion during pandemic in Maipú, Chile, during 2022 <p><strong>Objective:</strong> To compare the levels of depression, stress and anxiety according to Adventist affiliation during the pandemic in residents of the commune of Maipú, 2022.</p> <p><strong>Methods:</strong> Quantitative, analytical, correlational and cross-sectional study, applied to a sample of 176 inhabitants of the commune of Maipú, in the Metropolitan Region of Chile, using the modified Graffar scale to measure socioeconomic level and the Depression, Stress and Anxiety Scale (DASS-21) to measure levels of symptoms of depression, stress and anxiety in the population. The Mann Whitney U test was used to compare indicators of depression, anxiety and stress in both groups. The study was approved by an ethical committee.</p> <p><strong>Results:</strong> The Adventist population considering the sample obtained better indicators, with lower symptomatology level scores in depression and anxiety with values (p=0.002) and (p=0.00) respectively showing significant differences. As for stress, the levels were lower in the Adventist population but without significance with value (p=0.086).</p> <p><strong>Conclusions:</strong> There are protective factors in the practicing community that need to be identified and studied as they can benefit the community at large. These elements may be associated with the lifestyle practiced by Adventists as part of their tradition.</p> Agustín Hermosilla John Carreño Ismael Antonio Morales Ojeda Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v23i1.5289 Factors associated with hemoglobin levels in children under 6 months of age hospitalized in a pediatric center in Peru <p><strong>Introduction:</strong> <span class="NormalTextRun SCXW194293038 BCX0">Anemia is a condition in which there is a low concentration of hemoglobin (Hb) levels. Although many causes of anemia have been </span><span class="NormalTextRun SCXW194293038 BCX0">identified</span><span class="NormalTextRun SCXW194293038 BCX0">, there are few studies in which they are related to epidemiological factors in the first months of life. </span></p> <p><strong>Objective:</strong> To determine the factors associated with hemoglobin levels in children under 6 months of age hospitalized in a specialized pediatric center in Peru.</p> <p><strong>Methods:</strong> <span class="NormalTextRun SCXW194293038 BCX0">To </span><span class="NormalTextRun SCXW194293038 BCX0">determine</span><span class="NormalTextRun SCXW194293038 BCX0"> the factors associated with hemoglobin levels in children under 6 months of age hospitalized in a specialized pediatric center in Peru.</span></p> <p><strong>Results:</strong> <span class="TextRun SCXW194293038 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW194293038 BCX0">61.4% of the infants were women, and only 6.7% of the proportion of the studied population was less than 1 month old. 6.7% had a low birth weight, and 53.2% had a normal delivery. The level of anemia in hospitalized children under 6 months of age is 66.7%.</span></span>.</p> <p><strong>Conclusions:</strong> <span class="TextRun SCXW67441822 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW67441822 BCX0">The factors associated with hemoglobin levels were age, nutritional status, weight for length, and hospital causes. Likewise, an association was found between age and the median Hb in </span><span class="NormalTextRun SCXW67441822 BCX0">boys and girls</span><span class="NormalTextRun SCXW67441822 BCX0"> aged 0 to 5 months.</span></span><span class="EOP SCXW67441822 BCX0" data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559738&quot;:120,&quot;335559739&quot;:0,&quot;335559740&quot;:360}"> </span></p> Víctor Alfonso Mamani-Urrutia Rafael Durán-Galdo Carlos Gonzales-Saravia Alicia Bustamante-López Rubén Espinoza-Rojas Raffo Escalante-Kanashiro Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v23i1.5059 Academic interest in the therapeutic use of cannabis in nursing students from a private university in Chile <p><strong>Abstract</strong></p> <p><strong>Objective: </strong>To identify the academi interested related to the therapeutic use of cannabis in nursing students</p> <p><strong>Methods:</strong> It is an investigation from Gadamer's hermeneutical paradigm. The non-probabilistic sample of cases by criteria was made up of 20 key informants from the 3rd and 4th years of the Nursing Career; inclusion criteria: be a student enrolled in the school year and be up to date on the degree. Data collection was through the formation of two focus groups in 2018. Data reduction was manual, data transcription was performed using the Jefferson formula, rigorous and ethical criteria were met.</p> <p><strong>Results: </strong>3 categories emerged: Academic node, Disciplinary roles and Ethical-legal considerations. Students acknowledge linking the therapeutic use of cannabis to their curriculum, displaying relationships between it and its environment in the disciplinary functions related to the care role in care management, they view the educational role towards the community and consider a lack of research in the area, bioethics and legal aspects are mentioned for the third category.</p> <p><strong>Conclusions:</strong> There is academic interest in incorporating the therapeutic use of cannabis into university education, the care action is strongly recognized, the educational role is identified and is related to strategies and interventions towards the population; lack of thematic research development, administrative management is not mentioned. It is mentioned to involve bioethics and legal aspects in training specifically in the therapeutic use of cannabis.</p> <p><strong>Keywords </strong><strong>(Decs)</strong><strong>:</strong> Cannabinoids; Cannabis; Pain; Central nervous system diseases.</p> <p><strong> </strong></p> Alejandro Antonio Hernández Diaz Copyright (c) 1970 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v23i1.4379 Identification of palliative care requirement in hospital inpatients in internal medicine services in a peruvian reference hospital <p><strong><span data-contrast="auto">Introduction:</span></strong><span data-contrast="auto"> Hospitals of greater complexity tend to care for patients with advanced chronic diseases, which is why it is important to recognize the need for palliative care.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}"> </span></p> <p><strong><span data-contrast="auto">Objective:</span></strong><span data-contrast="auto"> To identify the proportion of patients who require palliative care in the medicine department of a Peruvian referral hospital.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}"> </span></p> <p><strong><span data-contrast="auto">Methodology:</span></strong><span data-contrast="auto"> Observational, analytical, cross-sectional study. All hospitalized patients were studied in the Department of Internal Medicine of the Peruvian hospital during the period April-May 2018. To determine the need for palliative care, the NECPAL CCOMS-ICO © instrument was used. The quantitative variables are presented as median and interquartile range (IQR); and numerical variables, such as frequencies and percentages. For the comparison of numerical variables, the Mann Whitney test was used and the chi-square test for categorical variables.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}"> </span></p> <p><strong><span data-contrast="auto">Results: </span></strong><span data-contrast="auto">They were evaluated in 281, where 102 (37.9%) required palliative care. The median age in patients requiring palliative care was 69.5 (IQR: 58-81) years. The median hospital stay in patients with and without the need for palliative care was 7 days (IQR: 4-11) and 9 days (IQR: 5-19) respectively, the mortality in patients with and without the need for palliative care was 37.25% and 4.19% respectively.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}"> </span></p> <p><strong><span data-contrast="auto">Conclusions:</span></strong><span data-contrast="auto"> There is a high frequency of need for palliative care in patients hospitalized in internal medicine wards, the requirement for palliative care was associated with higher mortality and hospital stay, which evidences the need for comprehensive and personalized care based on medical services specialized.</span><span data-ccp-props="{&quot;201341983&quot;:0,&quot;335551550&quot;:6,&quot;335551620&quot;:6,&quot;335559739&quot;:120,&quot;335559740&quot;:240}"> </span></p> Annie Velasquez-Manrique Claudia Benavides-Luyo Susan Chaupi-Rojas Sandra Andahua-Inuma Manuel Andrade-Acuña Rubén Sánchez-Ruiz Alonso Soto Copyright (c) 1970 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v22i3.4621 Identification of Human Papillomavirus genotypes in juvenile laryngeal papillomatosis. Three-year experience in a concentration hospital in Puebla, Mexico <p><strong>Background: </strong>Juvenile laryngeal papillomatosis (JLP) is a chronic benign disease from viral etiology, whose clinical course can be aggressive. In Mexico, the Human Papillomavirus (HPV) genotypes that cause this disease have been poorly studied.</p> <p><strong>Objective: </strong>To identify the HPV genotypes in patients with JLP in a reference Hospital in Puebla, Mexico.</p> <p><strong>Mehods: </strong>A retrospective descriptive study was performed in patients with JLP attended in a 3<sup>rd</sup> level care of the Instituto Mexicano del Seguro Social in Puebla, México, from 2018 to 2021. Medical records were revised. In all patients, HPV identification was performed by polymerase chain reaction for genomes 6, 11, 16 and 18 using specific oligonucleotides. Descriptive statistics were applied.</p> <p><strong>Results:</strong> 9 patients were included, 56% women, mean age 9.5 ±5.7 years; 7 patients were HPV-11 positive and 2 HPV-6. The mean age at diagnosis was 2.35 ±1.77 years, with an average of 12 ±11.56 surgical procedures; 5 patients were tracheostomy carriers, 4 had genotype 11; 8 patients were born vaginally, but no patient had maternal genital condylomatous lesions. In the patient born by cesarean section, transmission due to sexual abuse was documented.</p> <p><strong>Conclusions:</strong> The most frequent genotypes in patients with JLP in the south-central region of Mexico are HPV-6 and HPV-11, the latter one is predominating.</p> Arturo García-Galicia Clotilde Margarita Andrade-Bonilla Verónica Vallejo-Ruiz Blanca Elena Vallejo-Domínguez Janeth Ramírez-Mendoza Álvaro José Montiel-Jarquín Nancy Rosalía Bertado-Ramírez Jorge Loría-Castellanos Copyright (c) 2023 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v23i1.5088 Consumption of foods rich in antioxidants in outpatients with diabetic retinopathy at Hospital La Carlota during 2021 <p>The objective of this work was to assess the quality of the consumption of foods rich in antioxidants such as vitamin C, E and selenium, in a sample of 28 patients with diabetic retinopathy (DR) who attended outpatient consultation at the Institute of Vision, of the La Carlota Hospital, in February 2021. The research was observational, descriptive, cross-sectional, with an analytical component. Patients older than 20 years with DR were included, who agreed to participate in the food survey applied by hospital professionals. Sociodemographic and ophthalmological variables and food consumption were measured. Results: 60% of the cases were men, the mean age was 56 ± 13 years. Proliferative diabetic retinopathy (PDR) was the most frequent diagnosis. Regarding food consumption, the most frequently mentioned were eggs, onion, garlic, parsley, orange, banana, lemon, corn tortillas, chili peppers, avocado. It was almost zero intake of whole fiber, nuts and vegetable oils. The median consumption of vitamin C was 87.5 mg, vitamin E 13.9 mg, and selenium 36.7 mcg. Deficient consumption of these micronutrients was found in 63% of cases, especially in men. In this research, no statistically significant association was found between poor consumption of foods rich in antioxidants and PDR (X<sup>2</sup> p= 0.2). Conclusion: There is a marked deficit in the consumption of foods with a high contribution of antioxidants in patients with RD, but this situation does not affect the severity of the disease.</p> Raquel Karen García Lecca Raquel Martínez de Kurata Edward Samudio Márquez Javier Castillo Velázquez Copyright (c) 2021 Revista de la Facultad de Medicina Humana 2023-01-25 2023-01-25 23 1 10.25176/RFMH.v22i1.4121