Gastrointestinal stromaal tumor (GIST) in the jejunum
Tumor del estroma gastrointestinal (GIST) en yeyuno
DOI:
https://doi.org/10.25176/RFMH.v23i1.5309Keywords:
Gastrointestinal stromal tumor, cKit/CD117, midgastrointestinal hemorrhageAbstract
Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms that represent less than 3% of gastrointestinal neoplasms, with an incidence of 1 to 2 cases per hundred thousand inhabitants. It originates more frequently in the stomach and small intestine and is characterized by the expression of the tyrosine kinase growth factor receptor, CD117. Therefore, its diagnosis requires an immunohischemical study to rule it out from other mesenchymal tumors. However, enteroscopic imaging and analysis of the biopsy may suggest a preoperative diagnosis of probable GIST.
The case of a 62-year-old woman with rectorrhagia and recurrent anemia caused by mid-intestinal bleeding observed by capsule endoscopy is reported. Enteroscopy revealed a subepithelial ulcerated lesion in the proximal jejunum, and a biopsy was taken, the anatomopathological study of which suggested a gastrointestinal stromal tumor. The biopsy sample subjected to immunohistochemical studies confirms the suspicion of a cKit/CD117-positive GIST tumor. Surgical resection of the tumor with dimensions 4.2x3 cm is performed. After surgery, the patient was stable and under clinical follow-up until she was discharged. Clinical finding
Downloads
References
Akahoshi K, Oya M, Koga T, Shiratsuchi Y. Current clinical management of gastrointestinal stromal tumor. World J Gastroenterol. 2018;24(26):2806–17. Disponible en: https://doi.org/10.3748/wjg.v24.i26.2806
Blay JY, Kang YK, Nishida T, von Mehren M. Gastrointestinal stromal tumours. Nat Rev Dis Primer. 2021;7(1):1–22. Disponible en: https://doi.org/10.1038/s41572-021-00254-5
Al-Share B, Alloghbi A, Al Hallak MN, Uddin H, Azmi A, Mohammad RM, et al. Gastrointestinal stromal tumor: a review of current and emerging therapies. Cancer Metastasis Rev. 2021;40(2):625–41. Disponible en: https://doi.org/10.1007/s10555-021-09961-7
Parab TM, DeRogatis MJ, Boaz AM, Grasso SA, Issack PS, Duarte DA, et al. Gastrointestinal stromal tumors: A comprehensive review. J Gastrointest Oncol. 2019;10(1):144–54. Disponible en: https://doi.org/10.21037/jgo.2018.08.20
Mantese G. Gastrointestinal stromal tumor: Epidemiology, diagnosis, and treatment. Curr Opin Gastroenterol. 2019;35(6):555–9. Disponible: https://doi.org/10.1097/MOG.0000000000000584
Sorour MA, Kassem MI, Ghazal AEHA, El-Riwini MT, Abu Nasr A. Gastrointestinal stromal tumors (GIST) related emergencies. Int J Surg. 2014;12(4):269–80. Disponible en: https://doi.org/10.1016/j.ijsu.2014.02.004
Saad MK, Hajj IE, Saikaly E. Jejunal gastrointestinal stromal tumor (GIST): a case report presenting as life threatening emergency. Gastrointest Stromal Tumor [Internet]. el 20 de noviembre de 2020 [citado el 23 de noviembre de 2022];3(0). Disponible en: https://gist.amegroups.com/article/view/46162
gom169j.pdf [Internet]. [citado el 23 de noviembre de 2022]. Disponible en: https://www.medigraphic.com/pdfs/ginobsmex/gom-2016/gom169j.pdf
Pinilla-Lizarraga R, Claros-Beltrán N, Mayte-Arze G. Neoplasia Fusocelular - Tumor de Gist: Presentación de un caso. Cuad Hosp Clínicas. diciembre de 2020;61(2):51–7. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1179195
Moreno-Paquentín E, Caba Molina D, Sánchez-García J, Arrangoiz-Majul R, Cordera-González de Cosío F, Luque de León E, et al. Reporte de caso clínico de un tumor del estroma gastrointestinal (GIST) gigante y revisión bibliográfica. Cir Gen. junio de 2018;40(2):127–32. Disponible en: https://www.medigraphic.com/pdfs/cirgen/cg-2018/cg182j.pdf
Sashidharan P, Matele A, Matele U, Al Felahi N, Kassem KF. Gastrointestinal Stromal Tumors: A Case Report. Oman Med J. marzo de 2014;29(2):138–41. Disponible en: https://doi.org/10.5001/omj.2014.34
Joensuu H, Wardelmann E, Sihto H, Eriksson M, Sundby Hall K, Reichardt A, et al. Effect of KIT and PDGFRA Mutations on Survival in Patients With Gastrointestinal Stromal Tumors Treated With Adjuvant Imatinib: An Exploratory Analysis of a Randomized Clinical Trial. JAMA Oncol. el 1 de mayo de 2017;3(5):602–9. Disponible en: https://doi.org/10.1001/jamaoncol.2016.5751
Soriano-Lorenzo J, Lima-Pérez M, Soriano-García J, Zaldívar-Blanco K, Fleites-Calvo V. Tumores del estroma gastrointestinal. An Fac Med. abril de 2019;80(2):214–21. Disponible en: https://doi.org/10.15381/anales.802.16418
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Revista de la Facultad de Medicina Humana
This work is licensed under a Creative Commons Attribution 4.0 International License.
