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Systemic immunomodulatory therapy in the management of atopic dermatitis: the value of Tralokinumab

Terapia inmunomoduladora sistémica en el tratamiento de la dermatitis atópica: el valor de Tralokinumab

Authors

  • Sara Muñoz Ordóñez Departamento de Investigaciones, Fundación para la Investigación en Dermatología (FUNINDERMA), Bogotá, Colombia.
  • Jessika Alexandra Layos Facultad de Medicina, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
  • Maria Paula Garcia Lozano Facultad de Medicina, Universidad del Rosario, Bogotá, Colombia.
  • Yelson Alejandro Picón Jaimes Fac Ciències Salut Blanquerna, Univ Ramon Llul, Barcelona, España

DOI:

https://doi.org/10.25176/RFMH.v23i3.5593

Keywords:

Atopic Dermatitis, Tralokinumab, Immunomodulation, Interleukin-13, Immunosuppression Therapy

Abstract

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Author Biographies

Sara Muñoz Ordóñez , Departamento de Investigaciones, Fundación para la Investigación en Dermatología (FUNINDERMA), Bogotá, Colombia.

Médico

Jessika Alexandra Layos , Facultad de Medicina, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.

Médico

Maria Paula Garcia Lozano, Facultad de Medicina, Universidad del Rosario, Bogotá, Colombia.

Médico

Yelson Alejandro Picón Jaimes, Fac Ciències Salut Blanquerna, Univ Ramon Llul, Barcelona, España

Médico Magister en Epidemiología y Salud Pública Estudiante de Doctorado en Salud, Bienestar y Bioética

References

Kelly KA, Perche PO, Feldman SR. Therapeutic Potential of Tralokinumab in the Treatment of Atopic Dermatitis: A Review on the Emerging Clinical Data. Clin Cosmet Investig Dermatol. 2022; 15:1037-1043. DOI: 10.2147/CCID.S267217

Singh R, Taylor A, Shah MA, Strowd LC, Feldman SR. Review of Tralokinumab in the Treatment of Atopic Dermatitis. Ann Pharmacother. 2023; 57(3):333-340. DOI: 10.1177/10600280221105686

Drucker AM, Morra DE, Prieto-Merino D, Ellis AG, Yiu ZZN, Rochwerg B, et al. Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis. JAMA Dermatol. 2022; 158(5):523-532. DOI: 10.1001/jamadermatol.2022.0455

Institute of Medicine (US) Committee on the US Commitment to Global Health. The US Commitment to Global Health: Recommendations for the Public and Private Sectors. Washington (DC): National Academies Press (US); 2009. Summary. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK23788/

Silverberg JI, Toth D, Bieber T, Alexis AF, Elewski BE, Pink AE, et al. Tralokinumab plus topical corticosteroids for the treatment of moderate-to-severe atopic dermatitis: results from the double-blind, randomized, multicentre, placebo-controlled phase III ECZTRA 3 trial. Br J Dermatol. 2021; 184(3):450-463. DOI: 10.1111/bjd.19573

Gutermuth J, Pink AE, Worm M, Soldbro L, Bjerregård Øland C, Weidinger S. Tralokinumab plus topical corticosteroids in adults with severe atopic dermatitis and inadequate response to or intolerance of ciclosporin A: a placebo-controlled, randomized, phase III clinical trial (ECZTRA 7). Br J Dermatol. 2022; 186(3):440-452. DOI: 10.1111/bjd.20832

Soehoel A, Larsen MS, Timmermann S. Population Pharmacokinetics of Tralokinumab in Adult Subjects With Moderate to Severe Atopic Dermatitis. Clin Pharmacol Drug Dev. 2022; 11(8):910-921. DOI: 10.1002/cpdd.1113

Lai B, Phan K, Lewis N, Shumack S. A rare case of vernal keratoconjunctivitis in a patient with atopic dermatitis treated with tralokinumab. J Eur Acad Dermatol Venereol. 2022; 36(5):e343-e345. DOI: 10.1111/jdv.17824

Wang B, Goodman J, Roskos LK. Mechanistic modeling of a human IgG4 monoclonal antibody (tralokinumab) Fab-arm exchange with endogenous IgG4 in healthy volunteers. CPT Pharmacometrics Syst Pharmacol. 2022; 11(4):438-446. DOI: 10.1002/psp4.12738

Lozada-Martinez ID, Suarez-Causado A, Solana-Tinoco JB. Ethnicity, genetic variants, risk factors and cholelithiasis: The need for eco-epidemiological studies and genomic analysis in Latin American surgery. Int J Surg. 2022; 99:106589. DOI: 10.1016/j.ijsu.2022.106589

Adikusuma W, Irham LM, Chou WH, Wong HS, Mugiyanto E, Ting J, et al. Drug Repurposing for Atopic Dermatitis by Integration of Gene Networking and Genomic Information. Front Immunol. 2021; 12:724277. DOI: 10.3389/fimmu.2021.724277

Pérez-Fontalvo NM, De Arco-Aragón MA, Jimenez-García JDC, Lozada-Martinez ID. Molecular and computational research in low- and middle-income countries: Development is close at hand. J Taibah Univ Med Sci. 2021; 16(6):948-949. DOI: 10.1016/j.jtumed.2021.06.010

Published

2023-09-14 — Updated on 2023-09-28

Versions

How to Cite

Muñoz Ordóñez , S., Layos , J. A. ., Garcia Lozano, M. P. ., & Picón Jaimes, Y. A. (2023). Systemic immunomodulatory therapy in the management of atopic dermatitis: the value of Tralokinumab: Terapia inmunomoduladora sistémica en el tratamiento de la dermatitis atópica: el valor de Tralokinumab. Revista De La Facultad De Medicina Humana, 23(3), 176–178. https://doi.org/10.25176/RFMH.v23i3.5593 (Original work published September 14, 2023)