TY - JOUR AU - Sotelo, Pedro Paolo AU - Ramírez Calderón, Fanny Elizabeth AU - Quiñones Avila, María Del Pilar PY - 2019/10/10 Y2 - 2024/03/28 TI - CASTLEMAN DISEASE VARIANT OF POEMS SYNDROME. A CASE REPORT: SÍNDROME POEMS ASOCIADO A ENFERMEDAD DE CASTLEMAN. UN REPORTE DE CASO JF - Revista de la Facultad de Medicina Humana JA - Rev.Fac.Med.Hum VL - 19 IS - 4 SE - Clinical Case DO - 10.25176/RFMH.v19i4.2145 UR - https://revistas.urp.edu.pe/index.php/RFMH/article/view/2145 SP - 1 AB - <p><strong>Introduction:</strong> POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) syndrome is a rare multisystem disorder. Castleman disease is an atypical lymphoproliferative disorder of unknown cause, which can be associated to POEMS.</p><p><strong>Clinical Case:</strong> This is the case of a 37-year-old patient with 2-year history of numbness and weakness in lower limbs associated to multiple adenopathy, skin hyperpigmentation and hypertrichosis. Electromyography showed active chronic sensory-motor polyneuropathy of axonal type; and serum electrophoresis showed a monoclonal band of A Immunoglobulin lambda type. Submaxillary lymph node biopsy was consistent with Castleman Disease.</p><p><strong>Conclusion:</strong> This report highlights the fact that Castleman Disease is frequent among patients with POEMS syndrome, constituting a significant variant, and should always be ruled out. Furthermore, plasmapheresis could be a useful alternative among patients with severe neurological symptoms.</p><p>&nbsp;</p><p>&nbsp;</p> ER -