Revista de la Facultad de Medicina Humana https://revistas.urp.edu.pe/index.php/RFMH <p>The Revista de la Facultad de Medicina Humana (Rev. Fac. Med. Hum.) is edited by Instituto de Investigaciones en Ciencias Biomédicas of Universidad Ricardo Palma. This journal publishes original research articles in medicine and public health; adheres to the standards and recommendations of the ICMJE and COPE. It is an open access journal that is available in full text in Spanish and English.</p> <p> </p> en-US jhony.delacruz@urp.edu.pe (Dr. Jhony A. De La Cruz Vargas PhD, MCR, MD) dante.quinones@urp.edu.pe (Mg. Dante Quiñones) Fri, 28 Jun 2024 00:00:00 +0000 OJS 3.2.1.3 http://blogs.law.harvard.edu/tech/rss 60 Association Between Informal Employment and Positive COVID-19 Cases in Peru https://revistas.urp.edu.pe/index.php/RFMH/article/view/6484 <p><strong>Objectives:</strong> To identify the association between the number of informal workers and the number of positive COVID-19 cases in Peru.</p> <p><strong>Methods:</strong> Data from the National Institute of Statistics and Informatics of Peru and the National COVID-19 Database were used. Bivariate and multivariate linear regression analyses were conducted to assess the relationship between the number of informal workers, population density, altitude, and the number of positive COVID-19 cases.</p> <p><strong>Results:</strong> The bivariate analysis showed that the number of informal workers was significantly associated with positive cases in both high and low altitude regions (p&lt;0.001). In the multivariate analysis, informal workers (p&lt;0.001), population density (p=0.02), and altitude (p&lt;0.001) were found to be associated with the number of positive COVID-19 cases.</p> <p><strong>Conclusions:</strong> Informal workers are common in low- and middle-income countries where social security is lacking, and they depend economically on daily wages. Their situation worsened due to social mobility restrictions, which forced them to continue working and consequently increased their susceptibility to infection, further becoming a source of contagion.</p> Milagros Pascual-Guevara, Miguel Cabanillas-Lazo Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6484 Fri, 28 Jun 2024 00:00:00 +0000 Health without Borders: INICIB-URP leading Medical Education through Bioengineering and Mechatronic Technologies https://revistas.urp.edu.pe/index.php/RFMH/article/view/6701 <p>Medical education is at a turning point due to the rapid advances in biomedical technology and robotics in rehabilitation. This editorial examines the importance of integrating these innovations into medical curricula, highlighting statistics on medical education in Latin America and Peru, and discusses the challenges and opportunities for improving the training of future health professionals.</p> <p>In the 21st century, technology is redefining medicine and, consequently, medical education. Biomedical technology and robotics in rehabilitation offer new tools to enhance teaching and clinical practice. In Latin America, including Peru, it is crucial for medical schools to adapt their programs to incorporate these technologies and adequately prepare their students.</p> Mariela Vargas, Jose Cornejo, Jhony A. De La Cruz-Vargas Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6701 Tue, 16 Jul 2024 00:00:00 +0000 Is It Enough to Know That Tobacco Consumption Is Associated With Gastric Cancer? https://revistas.urp.edu.pe/index.php/RFMH/article/view/6472 <p>I sincerely appreciate the publication of the article on the prevention of gastric cancer in patients from Lima, Peru. It is encouraging to see research that addresses crucial issues for public health, especially in our national context.</p> <p>Gastric cancer remains a global concern, with significant incidence and mortality, and tobacco consumption emerges as one of the most important risk factors after Helicobacter pylori infection.</p> <p>In Peru, the situation is no different. Despite efforts to combat this disease, the incidence and mortality from gastric cancer remain worryingly high. Recent data show that gastric cancer accounts for a considerable proportion of cancer deaths in our country.</p> <p>It is essential that gastric cancer prevention is prioritized, focusing on raising awareness about the risks of smoking and promoting healthy lifestyles. This requires not only financial resources, but also a coordinated and committed approach by health authorities and society as a whole.</p> <p>I hope this letter serves as a call to action to more effectively address gastric cancer prevention in Peru.</p> Oscar Gregory Meza Gamboa Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6472 Fri, 28 Jun 2024 00:00:00 +0000 The Thin Line of Relationship Between Intimate Partner Violence and Depression https://revistas.urp.edu.pe/index.php/RFMH/article/view/6536 <p>Intimate partner violence and depression are serious and widespread problems worldwide. According to an analysis of prevalence data in 161 countries from 2000 to 2018 by the WHO, one in three women has suffered physical and/or sexual violence by their partner or sexual violence by someone who was not their partner, or both. In the Western Pacific, the prevalence is 20% and 22% in the European Region and high-income countries (1).</p> <p>In our country, according to the results of Endes 2018, 63.2% of women aged 15 to 49 years were victims of domestic violence at some point in their lives by their husband or partner. According to the type of violence exerted, 30.7% of the victims suffered physical violence, 58.9% psychological or verbal violence, and 6.8% sexual violence.</p> Romina Pinedo Linasca, Yudith Cauna Orocollo Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6536 Fri, 28 Jun 2024 00:00:00 +0000 Environment, Policies, and Addictions to Social Networks Among University Students https://revistas.urp.edu.pe/index.php/RFMH/article/view/6325 <p>The two main topics were essentially addressed. Firstly, and of great concern in the university setting, is related to addictive behaviors in the use of social media by students. Secondly, less explored in the country, is the various policies being implemented to address this phenomenon.</p> Alvaro Valdez Roca, Alberto Valdez Barboza Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6325 Fri, 28 Jun 2024 00:00:00 +0000 Drug dependence and suicide, a growing problem https://revistas.urp.edu.pe/index.php/RFMH/article/view/6474 <p>Both nationally and internationally, drug dependence and suicide are problems with a high prevalence rate and in recent years have had an upward trend, bringing with them multiple social and health consequences. The relationship between drug dependence and suicide is statistically significant, with drug-dependent patients having a risk up to six times higher of attempting suicide compared to the general population. Therefore, it is important to know the risk factors associated with suicidal behavior in drug-dependent patients, in order to improve the prevention, treatment and prognosis of both problems. Although it is true that many of the risk factors associated with suicidal behavior are already known, these factors in the context of drug-dependent patients are still a subject that has not been investigated as much, and particularly at the national level, the variability of the factors according to the different regions, multiculturalism, socioeconomic strata, etc., are not taken into account. Therefore, it is recommended to increase the research budget, emphasizing on the variables and populations already mentioned, in order to have better qualified health personnel in the problem in question.</p> <p>&nbsp;</p> Hector Leon Soto Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6474 Fri, 28 Jun 2024 00:00:00 +0000 Dimensions of well-being: exploring quality of life in patients with cancer in a pain therapy unit https://revistas.urp.edu.pe/index.php/RFMH/article/view/6639 <p>Uric Acid, a potent endogenous antioxidant, has recently been investigated for its potential relationship with neurodegenerative diseases. This letter proposes that uric acid could serve as a predictive marker of cognitive decline in neurodegenerative conditions. Recent studies suggesting a correlation between elevated uric acid levels and a lower risk of cognitive decline are reviewed, advocating for further research to confirm these findings. Additionally, the clinical implications of using uric acid as a potential biomarker in neurological practice are discussed.</p> Patricia Pernia Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6639 Fri, 28 Jun 2024 00:00:00 +0000 Dimensions of Well-being: Exploring Quality of Life in Cancer Patients in a Pain Therapy Unit https://revistas.urp.edu.pe/index.php/RFMH/article/view/6574 <div class="QFw9Te BLojaf"> <div id="ow352"><span class="jCAhz JxVs2d ChMk0b"><span class="ryNqvb">Given that preserving the feeling of well-being in cancer patients in palliative care is a predominant objective in cancer control, there are various instruments for measuring quality of life;</span></span> <span class="jCAhz JxVs2d ChMk0b"><span class="ryNqvb">However, it remains a challenge to quantify it and compare it between individuals, so it is essential to be diligent when selecting an instrument.</span></span></div> </div> Jimena Alexandra Villacorta Ramos Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6574 Fri, 28 Jun 2024 00:00:00 +0000 Near-Fatal Asthma: Case Report in the Emergency Department of Hospital Santa Rosa https://revistas.urp.edu.pe/index.php/RFMH/article/view/6602 <p><strong>Introduction</strong>: Asthma, classically, is defined as a chronic inflammatory disease of the airways; characterized by a history of respiratory symptoms, such as wheezing, shortness of breath, chest tightness, and cough, that vary over time and in intensity. Near-fatal asthma are situations in which asthma exacerbations can lead to cardiorespiratory arrest, orotracheal intubation and mechanical ventilation, admission to an intensive care unit (ICU); Knowing the characteristics and risk factors that predict this situation in a patient who arrives at the emergency room is very important for early action. <strong>Clinical case</strong>: We present a 23-year-old patient with a history of asthma since he was 5 years old and irregular treatment; with a stay in the ICU and on mechanical ventilation for almost fatal asthma 8 months before; the clinical signs and the arterial blood gas analysis predicted an almost fatal asthma condition, which is why it was decided to intubate and mechanically ventilate the patient, and then transfer to the ICU with a favorable evolution and discharge 9 days after admission. <strong>Conclusion</strong>: Patient who already had a previous admission for almost fatal asthma and admission to the ICU, persistence of desaturation in the face of rescue treatment for said pathology; determining factors for deciding rapid sequence orotracheal intubation and transfer to the intensive care unit; with remission of the admission clinical picture and prompt discharge of the patient.</p> William Rojas Pérez, Jorge L. Delgado Del Aguila Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6602 Fri, 28 Jun 2024 00:00:00 +0000 Heart Failure with Recovered Left Ventricle Ejection Fraction. Case Report https://revistas.urp.edu.pe/index.php/RFMH/article/view/6255 <p>Heart failure with recovered ejection fraction is defined as the improvement of left ventricular systolic function (LVEF) to values ≥ 40%, after having presented a reduced LVEF (&lt; 40%) at a previous time and ≥10% absolute improvement in LVEF. It is a chronic and dynamic condition with a high risk of relapse and deterioration, so close monitoring and optimal medical therapy are essential for its management. A case is presented of a young male patient with dilated cardiomyopathy with severe left ventricular systolic dysfunction, who with neurohormonal therapy for heart failure, showed rapid clinical recovery and improvement of ejection fraction and left ventricular remodeling. Further studies are needed to better understand this condition and its long-term treatment.</p> Omar Augusto Diaz Cucho Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6255 Fri, 28 Jun 2024 00:00:00 +0000 Surgical therapy in duodenal-jejunal hemorrhagic diverticula, case report and bibliographic review. https://revistas.urp.edu.pe/index.php/RFMH/article/view/6434 <p><strong>Summary:</strong></p> <p><strong>Introduction:</strong> Diverticula are intestinal saccular dilations; They can be classified as false or true, congenital or acquired. Complications can be serious, bleeding is the most characteristic sign.</p> <p><strong>Case report:</strong> Female, 68 years old, the condition began with upper digestive bleeding, endoscopic studies did not show any bleeding site; intestinal transit reported 2 duodenal diverticula. Due to multiple transfusions and hospitalizations, surgery was scheduled. Two duodenal diverticula and multiple diverticula were found in the jejunum. Duodenal diverticulectomies and segmental resection of the jejunum with entero-entero anastomosis were performed. During the post-surgery period she presented intestinal fistula, which was resolved with mixed nutrition.</p> <p><strong>Discussion:</strong> Intestinal transit revealed diverticula as a probable cause of bleeding. Since there were no minimally invasive options as determined by the guidelines, less morbid surgical treatment was provided.</p> <p><strong>Conclusions:</strong> In the absence of endoscopic or endovascular options, surgical intervention is a viable option; however, each case must be individualized to offer the lowest morbidity and mortality rate.</p> Williams Trinidad Rodríguez, José Manuel Carlos Segura-González, Ariadna Rodríguez-Reyes, Daniela Vidal-Santiago Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6434 Wed, 03 Jul 2024 00:00:00 +0000 Kaposi's Sarcoma and Bartonella Coinfection in HIV-Positive Patient https://revistas.urp.edu.pe/index.php/RFMH/article/view/6605 <p><strong>Introduction: </strong>Kaposi's sarcoma is a multifocal malignant neoplasm of endothelial cells, its etiological agent is HHV-8 and it constitutes one of the defining pathologies of AIDS. It represents approximately 12% of cancers diagnosed in people living with HIV. Bacillary angiomatosis (AB) is a rare infectious disease caused by bacteria of the genus Bartonella spp., transmitted by vectors such as fleas, lice, and mosquitoes. In patients with human immunodeficiency virus (HIV) infection with a CD4+ T-cell count &lt;100 cells/µL, it is associated with angiomatous lesions with neovascularization that involve the skin and, to a lesser extent, mucous membranes, liver, spleen, and bones.</p> <p><strong>Clinical case: </strong>the case of a 48-year-old male patient with a history of HIV on HAART for 15 years, who was admitted for an outpatient infectious disease clinic due to violaceous nodular lesions in the right and left MMII, upper eyelid. left and oropharynx. During hospitalization, a blood culture report was obtained that was positive for Bartonella and a biopsy result of a lower limb lesion concluded that Kaposi's Sarcoma was present. Upper gastrointestinal endoscopy and chest and abdominal tomography were performed, which showed the visceral and systemic involvement of Kaposi's Sarcoma. The HIV genotype is performed, resulting in resistance to antiretrovirals, so the medication is changed and chemotherapy is started, with the patient showing a good response and improvement.</p> <p><strong>Conclusion: </strong></p> <p>HIV-related Kaposi's Sarcoma affects AIDS patients in a much more severe, aggressive, and fulminant manner compared to other immunodeficient groups. However, when presenting characteristic lesions, we must consider its main differential diagnosis: Bacillary Angiomatosis, which, even very uncommonly, may occur simultaneously.</p> <p>&nbsp;</p> <p><strong>KEYWORDS:</strong></p> <p>Kaposi sarcoma, HIV, AIDS, Bacillary angiomatosis. (Source: MeSH – NLM)</p> Roger Antonio Sernaque Mechato, Clariza Biminchumo Sagastegui, Diego Alejandro Jimenez Mercado, Jesús Dario Toledo de la Torre, Flor Milagros Mendoza Barreto Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6605 Fri, 28 Jun 2024 00:00:00 +0000 Acute Benign Childhood Myositis Due to Bartonella henselae: A Rare Pathogen https://revistas.urp.edu.pe/index.php/RFMH/article/view/6549 <p><span style="font-weight: 400;">Acute benign myositis of childhood (ABIM) is an inflammatory pathology of the musculoskeletal system, it usually manifests with pain in the lower limbs associated with elevation of creatine phosphokinase (CPK). It is a rare condition, but if it occurs, it appears after a flu case, frequently associated with influenza A and B viruses. The case of a school-age girl with myalgia in lower limbs, fever and elevated CPK, diagnosed with MABI, with positive IgG to </span><em><span style="font-weight: 400;">Bartonella henselae</span></em><span style="font-weight: 400;">. It is considered important to report the case due to the little information available about this disease both in the country and in Latin America, in addition, to review the issue since there are no previous reports in Peru about </span><em><span style="font-weight: 400;">Bartonella henselae</span></em><span style="font-weight: 400;"> as the etiological agent of MABI; Likewise, discuss management and how to reduce unnecessary hospitalizations.</span></p> José Paz-Vargas, Gabriela Rivera-Saucedo, Cynthia Legna Huby Muñoz, Marco Antonio Alpiste Díaz Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6549 Fri, 28 Jun 2024 00:00:00 +0000 Weight Stigma and Its Association With Nutritional Status in Students of Health Careers in a Private University in the Region of Ñuble, Chile https://revistas.urp.edu.pe/index.php/RFMH/article/view/6457 <p><strong>Introduction:</strong> Obesity and overweight constitute global public health challenges, negatively impacting more than one billion people. They are accompanied by significant psychological and social consequences, including the stigma associated with weight, with severe repercussions on mental and physical well-being. Health professionals are directly involved with this problem; however, few studies address weight stigma in Chile. <strong>Objective:</strong> To relate nutritional status (BMI) and the level of weight stigma in university students of health careers in the region of Ñuble, Chile. <strong>Methodology:</strong> Observational design of correlational and cross-sectional scope. The GAMS-27 scale was applied to assess weight stigma and BMI to evaluate the nutritional status of 156 students of health careers. Chi2 tests of independence and binary logistic regression were applied to evaluate the association between the variables, with the R statistical package version 4.3.0. <strong>Results:</strong> A statistically significant association was found between weight stigma and nutritional status (p=0.0145). Presenting normal BMI (p=0.0163) and being female (p=0.0156) were associated with a higher probability of presenting weight bias. <strong>Conclusions:</strong> The present study identified a statistically significant association between weight stigma and nutritional status in college students. It is vital to promote education regarding weight stigma in college students to avoid bias and improve respect for future users.</p> Kevin Retamal, Krishna Gutiérrez, Pia Rojas Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6457 Fri, 28 Jun 2024 00:00:00 +0000 Kinetics of the release of platelet-derived growth factor (PDGF-BB) derived from human umbilical cord platelet-rich plasma. https://revistas.urp.edu.pe/index.php/RFMH/article/view/6703 <p><strong>Introduction:</strong> The use of cord blood (UC) offers numerous advantages in regenerative medicine. Platelet-rich plasma (PRP) is a source of growth factors where its dynamics over time have been evaluated in peripheral blood; however, its evaluation in UC blood has not been studied. <strong>Objective:</strong> To evaluate the kinetics of PDGF-BB release from PRP obtained from UC blood. Materials and methods: In vitro experimental study. UC blood samples were collected from 6 term deliveries of healthy pregnant women between 18 and 36 years of age who attended the Cayetano Heredia Hospital in Lima-Peru. The samples obtained were centrifuged at 900 g for 10 minutes to prepare the PRP. Activation was performed with 10% calcium gluconate (GLu.Ca) and divided into 4 aliquots: (i) without activator; (ii) 1 hour; (iii) 24 hours; (iv) 48 hours. PDGF-BB quantification was evaluated by ELISA method. <strong>Results:</strong> The mean ± standard deviation of PDGF-BB concentration measured at 1 hour, 24 hours and 48 hours were 6127.9 ± 101.6, 6197.5 ± 34 and 6176.8 ± 63.3 respectively. The kinetics of PDGF-BB released by PRP showed constant values during the 48 hours. <strong>Conclusions:</strong> PDGF-BB release from PRP obtained from UC blood was rapidly induced and remained constant and sustained during the first 48 hours after activation.</p> Pedro Alberto Aro Guardia, Ana Peralta, Andrea Nisi, Christian Lezama, Carmen Palomino, William Bocangel, Rodrigo Paredes, José Aguilar Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6703 Fri, 28 Jun 2024 00:00:00 +0000 Stress Level and the Use of Coping Strategies of Parents of Autistic Children https://revistas.urp.edu.pe/index.php/RFMH/article/view/6606 <p><strong>Introduction:</strong><span style="font-weight: 400;"> Obesity and overweight constitute global public health challenges, negatively impacting more than one billion people. They are accompanied by significant psychological and social consequences, notably weight stigma, which has severe repercussions on mental and physical well-being. Health professionals are directly involved with this issue; however, few studies address weight stigma in Chile. </span><strong>Objective:</strong><span style="font-weight: 400;"> To examine the association between nutritional status (BMI) and the level of weight stigma in university students from health-related fields in the Ñuble region, Chile. </span><strong>Methodology:</strong><span style="font-weight: 400;"> A cross-sectional descriptive observational design was used. The GAMS-27 scale was applied to evaluate weight stigma, and BMI was used to assess the nutritional status of 156 health career students. Chi-square independence tests and binary logistic regression were applied to evaluate the association between variables, using R version 4.3.0 statistical software. </span><strong>Results:</strong><span style="font-weight: 400;"> A statistically significant association was found between weight stigma and nutritional status (p=0.0145). Having a normal BMI (p=0.0163) and being female (p=0.0156) were associated with a higher likelihood of presenting weight bias. </span><strong>Conclusions:</strong><span style="font-weight: 400;"> This study identified a statistically significant association between weight stigma and nutritional status in university students. It is vital to promote education regarding weight stigma among university students to prevent prejudice and enhance respect towards future users.</span></p> Lorela La Torre Atusparia, Jesús Enrique Talavera, Luis Roldan, Manuel Loayza Alarico Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6606 Fri, 28 Jun 2024 00:00:00 +0000 Cervical Cancer During the COVID-19 Pandemic in Rural Communities of Ayacucho https://revistas.urp.edu.pe/index.php/RFMH/article/view/6488 <p><strong>Introduction: </strong>Due to the COVID-19 pandemic, vulnerable rural women faced significant challenges.</p> <p><strong>Objective: </strong>To explore the situation of cervical cancer during the pandemic from an intercultural perspective among rural women in Ayacucho in 2021.</p> <p><strong>Methodology: </strong>Mixed-method research with a concurrent triangulation design. Sample: Healthcare providers and rural women. Purposeful and reasoned sampling. Techniques: Surveys, in-depth interviews. Data analysis: Data systematization using Excel, SPSS for quantitative data, and Atlas.ti for qualitative data. Level of validity and confidence: triangulation.<br><strong>Results: </strong>Information from surveys and interviews was contrasted, revealing that the problem may have alternative solutions within the knowledge of the same communities<strong>.<br>Conclusion: </strong>Women reported lack of awareness, insufficient information in the Quechua language, and undervaluation of their traditional knowledge. Fear and contagion concerns prevented them from seeking healthcare services. Services were reduced, redirected, or discontinued, often due to budget constraints.</p> Lucy Orellana de Piscoya Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6488 Fri, 28 Jun 2024 00:00:00 +0000 Effect of Averrhoa carambola L. on the Skin in an Animal Model of Hypertrophic Scarring https://revistas.urp.edu.pe/index.php/RFMH/article/view/6538 <p><strong>Introduction:</strong> Hypertrophic scarring in the skin represents a serious global public health problem, as it physically and emotionally affects people who suffer from it. This makes it necessary to investigate new alternatives for its prevention and treatment. The objective of the study was to compare the effect of <em>Averrhoa carambola L.</em> (star fruit) on the skin under an animal model of hypertrophic healing. <strong>Methods:</strong> Experimental study; 10 male New Zealand breed rabbits were used, between 3 and 4 months old, with an average weight of 3 to 3.5Kg. The creation of hypertrophic scars in the ears of rabbits was induced under the model described by Morris et al. One of the groups received 1 mL of a 10% aqueous solution of the lyophilized star fruit, while the other received 1 mL of triamcinolone acetate; in both groups the application was intralesional and weekly in a month. After the treatment, under sedation, only the hypertrophic scars were extracted using a biopsy punch and the tissues were preserved in 10% formalin for subsequent pathological examination. <strong>Results:</strong> The group that received star fruit solution significantly improved the dermis and epidermis in the hypertrophic scars on the ears of rabbits that received treatment. When compared with the group that received triamcinolone acetonide, there were no statistically significant differences. <strong>Conclusion:</strong> The lyophilized aqueous extract of star fruit at 10% demonstrated a similar effect compare to triamcinolone acetonide (treatment of choice) in reducing the fibrosis of hypertrophic scars in the ears of rabbits.</p> <p><strong>Keywords:</strong> <em>Averrhoa carambola L.</em>, triamcinolone, hypertrophic scar, animal models. (MeSH/NLM)</p> Alberto Córdova-Aguilar, Elydia Mujica-Albán, José Manuel Ortiz-Sánchez, Silvia Suárez-Cunza, Rodrigo Iglesias-Bustamante, Daniel José Blanco-Victorio Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6538 Fri, 28 Jun 2024 00:00:00 +0000 Self-medication in students of the medical school of a university in northern Peru 2023 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6510 <p><strong>Objective</strong>: Describe self-medication and its relationship with sociodemographic characteristics in students of the medical school of a university in northern Peru 2023. <strong>Methodology</strong>: An observational, cross-sectional and prospective design was used with 301 participants, using the CAuM-ovr questionnaire to collect data. <strong>Results</strong>: 83.4% of the students self-medicated. The bivariate analysis revealed that belonging to medical school significantly increased the probability of self-medication (p=0.0001, OR=26.4), as did having a salary greater than 1,500 soles (p=0.01, OR= 2,26). The main reasons included symptoms not considered serious enough to see a doctor (39%). Regarding the level of knowledge, a high percentage (94.8%) did not request information about medications and 94% believed in the influence of advertising on their purchasing decisions. Attitudinally, 60.6% occasionally consulted a specialist for health problems, while 58.6% bought medications recommended by advertising. <strong>Conclusion</strong>: The frequency of self-medication is high among these students, which indicates a continuous risk practice despite their health training.</p> <p><strong>Key words:</strong> Self Medication; Students; Schools Medical; Attitudes; Knowledge. (source: MeSH NLM)</p> Estefany Sánchez Chamba, Olivia Santamaría Veliz, Pamela Huanambal Esquén, Erick Giancarlo Suclupe Farro Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6510 Fri, 28 Jun 2024 00:00:00 +0000 Quality of Life in Type 2 Diabetes Mellitus Patients https://revistas.urp.edu.pe/index.php/RFMH/article/view/6625 <p><strong>Introduction:</strong> Type 2 diabetes mellitus in the Americas affects approximately 62 million people, recognized as the most common chronic disease in the countries. It is estimated that by 2030, population growth, aging, urbanization, and lifestyle changes will lead to a 54% increase in diabetes, significantly impacting quality of life.</p> <p><strong>Objective:</strong> To determine the level of quality of life among patients with type 2 diabetes mellitus in the Province of Barranca, Lima Region, Peru.</p> <p><strong>Methods:</strong> Observational study with a descriptive design. The study population consisted of 242 patients attending a public hospital in the Province of Barranca, with a random sample of 144 patients. Data collection was conducted in the second quarter of 2021 through interviews using the WHOQOL-BREF questionnaire. Data analysis was performed using SPSS v.24 software.</p> <p><strong>Results:</strong> 69% of the patients were female, aged between 40-64 years, with a mean age of 58 years. The quality of life was moderate (86%), with the social dimension rated as high (74%), while the physical dimension was rated as low (64%). When analyzed by gender, both males and females predominantly reported moderate quality of life, and when grouped by age, those over 65 years rated their quality of life as low (29%).</p> Nicole Solange Cadenillas-Maguiña, Mayra Alejandra Rosas-Castillo, Marisa Esperanza Morillas, Evanilda Souza de Santana Carvalho, Kattia Ochoa Vigo Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6625 Fri, 28 Jun 2024 00:00:00 +0000 Effect of Consumption of Camu Camu Fruit Extract on Sperm DNA Integrity in Mice Pretreated with a Single Dose of Cyclophosphamide https://revistas.urp.edu.pe/index.php/RFMH/article/view/6682 <p><strong>Introduction</strong>: <em>Myrciaria dubia</em> known as “camu camu” is a fruit that grows in the Amazon and its main characteristic is its high content of vitamin C. Ascorbic acid has a protective role in spermatogenesis as it is a compound that has excellent reducing action. The purpose of this research was to evaluate <em>in vivo</em> the cytoprotective capacity of the aqueous extract of the fruit of Myrciaria dubia (Kunth) McVaugh “camu-camu” against the mutagenic damage produced by the antineoplastic drug cyclophosphamide (CP) on the male germ line. <strong>Methodology:</strong> Mice (n= 60) were divided into five treatment groups: T1= negative control (without treatment); T2 ingested the aqueous extract (10mgkg<sup>-1</sup>), T3 ingested the aqueous extract (50mgkg<sup>-1</sup>), T4 ingested the aqueous extract (100mgkg<sup>-1</sup>); T5 is the positive control. All of them were injected with a single dose of CP (50 mgkg<sup>-1</sup>) intraperitoneally. Treatment with camu-camu continued for 45 days, then the mice were euthanized to determine sperm quality and the frequency of DNA damage using the Index protocol. Sperm DNA fragmentation – Halomax protocol. <strong>Results</strong>: The effect of camu-camu extract was observed in all trials (p&lt; 0.05) compared to the negative control. Group T4, which was administered the highest concentration of the aqueous extract of the fruit, evidenced the cytoprotective effect of camu-camu (p&lt; 0.05). <strong>Conclusion</strong>: The damaging effect on DNA due to the oxidative action of CP is inhibited by the aqueous extract of the “camu camu” fruit.</p> Jose Luis Pino Gaviño, Carlos Bell Cortez, Pilar Valeria Pino Velásquez, Jacquelyne Zarria Romero, Nilda Oliveros Rodríguez, Betty Shiga Oshige Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6682 Fri, 28 Jun 2024 00:00:00 +0000 Anthropometric Profile and Maximum Serve Speed in Male Tennis Players at a Peruvian Sports Medical Center https://revistas.urp.edu.pe/index.php/RFMH/article/view/6677 <p><strong>Objective: </strong>To evaluate the relationship between anthropometric profile and serve speed in male Peruvian tennis players.</p> <p><strong>Methods: </strong>A quantitative, observational, cross-sectional, and analytical study was conducted with 79 male tennis players from the FiXU sports medical center in Lima, Peru, during 2023 and 2024. Variables such as height, weight, BMI, and limb dimensions were measured. Serve speed was assessed using a calibrated speed gun.</p> <p><strong>Results: </strong>The average serve speed was 94.38 km/h (±9.98). The average height of the players was 174.61 cm (±4.17) and the average weight was 72.20 kg (±6.97). Height (r=0.796) and weight (r=0.533) showed significant correlations with serve speed. Weekly playing hours (r=0.611) and years of experience (r=0.435) also showed positive associations. Linear regression identified height (B=1.91, p&lt;0.001), weight (B=0.76, p&lt;0.001), and forearm length (B=6.00, p&lt;0.001) as significant predictors of serve speed.</p> <p><strong>Conclusion: </strong>Height and weight are significant predictors of serve speed in Peruvian tennis players. Limb measurements and years of experience positively influence serve speed, while BMI showed no significant correlation.</p> Diana Santisteban, Horus Viru-Flores, Helman Roque Quezada, Jamee Guerra Valencia, Robert Vega-Vega, Juan Carlos Ezequiel Roque-Quezada Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6677 Fri, 28 Jun 2024 00:00:00 +0000 Description of genetic factors associated with suicidal behavior and suicide: a topical review https://revistas.urp.edu.pe/index.php/RFMH/article/view/6309 <p><strong>Introduction:</strong><span style="font-weight: 400;"> Suicide and suicidal behaviors (SC) are a complex and multidetermined phenomenon in which different genetic, environmental and individual factors interact. The objective of this study was to carry out a review of the genetic factors associated with suicidal behavior described in the literature of the last 10 years. </span><strong>Methods:</strong><span style="font-weight: 400;"> A search was made of all available articles, both review articles, case reports and management guidelines under the descriptors in health sciences (DeCS) Suicidal behavior, suicide, depression, exome, genetic markers, genetic variation, human genome, serotonin, norepinephrine, dopamine, computational biology in the databases of Google scholar, LILACS, PubMed and ClinicalKe, official websites such as those of the World Health Organization (WHO) and the Ministry of Health and Social Protection of Colombia were consulted. </span><strong>Development:</strong><span style="font-weight: 400;"> Genetic studies of CS have been trying for decades to find the "suicide gene", in order to prematurely identify those people with a higher risk of making suicide attempts and prevent them from becoming victims; however, these studies failed to find a gene or group of genes that differentiated between suicidal and nonsuicidal subjects. This type of technology gave rise to genome-wide association studies (GWAS), with which some authors wanted to demonstrate the differences in the genome of patients with suicidal ideas. </span><strong>Conclusions:</strong><span style="font-weight: 400;"> Knowledge of the genetic factors involved may lead to the possibility of identifying individuals with a higher risk of developing suicidal behavior, thus having better tools and receiving a more mechanistic vision to explore the underlying intermolecular network and prevent deaths from it. cause.</span></p> Sandra Constanza-Cañón, Natalia García-Restrepo, Lina María Aluma-Betancourt, Daniela Botero-Peláez, Mariana Devia-Cabrera, Elisa Rojas-Vargas, Laura Manuela Sánchez-Pinto, Santiago Piedrahita-Muñoz, Verónica Hurtado-Salazar, María Manuela Rodriguez-Gutierrez Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6309 Fri, 28 Jun 2024 00:00:00 +0000 Global research on use of artificial intelligence in imaging for breast cancer detection: bibliometric analysis https://revistas.urp.edu.pe/index.php/RFMH/article/view/6407 <p><strong>Introduction:</strong><span style="font-weight: 400;"> Breast cancer remains one of the most prevalent cancers globally, specifically the most common in females. The use of artificial intelligence promises to contribute to early diagnosis through imaging. Previously, the landscape and evolution of this scientific production have not been described.</span></p> <p><strong>Methods:</strong> <span style="font-weight: 400;">Cross-sectional bibliometric study using Scopus as the data source. The bibliometrix package in R was employed for calculating bibliometric indicators and visualizing the results.</span></p> <p><strong>Results:</strong><span style="font-weight: 400;"> 1292 documents published between 1989 and 2024 were selected. 75.3% (n=973) were articles with primary data, followed by 16.2% (n=209) corresponding to reviews. An international collaboration rate of 26.5% was identified, with an annual production growth of 10.78%. It was observed that risk classification through screening, digital breast tomosynthesis, transfer learning, segmentation, and feature selection were the most commonly used keywords. In the last five years, deep learning and mammography have been the most popular topics. International collaboration has been led by the United States, China, and the United Kingdom.</span></p> <p><strong>Conclusions:</strong> <span style="font-weight: 400;">A notable growth in global research on the use of artificial intelligence in breast cancer imaging for detection was identified, particularly since the 2010s, primarily through the publication of articles with primary data. The relationship between artificial intelligence and imaging for breast cancer diagnosis has focused on risk and prediction.</span></p> Juan Guillermo Murillo León, Valentina Espinosa Rivero, Isabella Saportas Peláez, Luis Enrique Calderón Mina , Angie Paola Cortes Sanjuanelo , Sebastian Alejandro Arias Tamayo, Nury Liseida Guevara Rosero, Manuel Cantillo Reines , Ciro Daniel Galeano Ortiz, Yelson Alejandro Picón Jaimes Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6407 Fri, 28 Jun 2024 00:00:00 +0000 Peripheral neuropathies, B vitam Vitamins B1, B6, and B12 and Peripheral Neuropathies: A Systematic Review of the Literature. https://revistas.urp.edu.pe/index.php/RFMH/article/view/6686 <p>The term peripheral neuropathy includes very varied and complex conditions that present difficulties in their diagnostic and therapeutic approach. One of the factors underlying these entities is the deficiency of neurotrophic vitamins B1, B6 and B12.</p> <p>Given the uncertainity and poorly known extremes of this subject and the empirical approach when using the therapeutic resources, a systematic search of the literature has been carried out trying to organize and base on scientific evidence the ideas and conflicting points that have presided over the approach to the issue by the professionals concerned by it.</p> <p>This study serves as the basis for an attempt at expert consensus that promotes a series of recommendations that rationalize and facilitate the management of the issue in clinical practice.</p> John Longa López, José Luis Dinamarca-Montecinos, Koni Mejía-Rojas, Astrid Cecilia Bernaola Cuadros, Jessica Beatriz Ampuero Bárcena, Leonardo Palacios-Sánchez, Mariano Fernández-Fairen Copyright (c) 2024 Revista de la Facultad de Medicina Humana http://creativecommons.org/licenses/by/4.0 https://revistas.urp.edu.pe/index.php/RFMH/article/view/6686 Fri, 28 Jun 2024 00:00:00 +0000