Hallazgos microscópicos del tejido pulmonar y los músculos respiratorios en la Enfermedad Pulmonar Obstructiva Crónica (EPOC): Microscopic findings of lung tissue and respiratory muscles in Chronic Obstructive Pulmonary Disease (COPD)

Tales Lyra de Oliveira; Tacio Nertan Cartaxo de Souza; Byron Martins Lucena; Fernanda Mayara Santos Santana; Lysien Ivania Zambrano; Ana Rose de Carvalho Araujo; Ana Lúcia de Gusmão Freire

doi:10.25176/RFMH.v20i1.2447

Authors

Tales Lyra de Oliveira 1) Facultad de Medicina, Universidad Municipal de São Caetano del Sur, São Paulo, Brasil. 2) Unidad de Hipertensión, Instituto del Corazón, Facultad de Medicina, Universidad de Sao Paulo, São Paulo, Brasil. http://orcid.org/0000-0003-4831-3009
Tacio Nertan Cartaxo de Souza Instituto de Ciencias Biológicas y de la Salud, Universidad Federal de Alagoas, Maceió, Brasil. http://orcid.org/0000-0003-1385-8949
Byron Martins Lucena Municipalidad de Maceió, Maceió, Brasil. http://orcid.org/0000-0002-2222-8351
Fernanda Mayara Santos Santana Facultad de Medicina, Universidad Federal de Alagoas, Maceió, Brasil. https://orcid.org/0000-0001-6920-937X
Lysien Ivania Zambrano Departamento de Ciencias Morfológicas, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras. http://orcid.org/0000-0001-9002-5807
Ana Rose de Carvalho Araujo Facultad de Fisioterapia, Universidad Estatal de Ciencias de la Salud de Alagoas, Maceió, Brasil. http://orcid.org/0000-0002-8050-2793
Ana Lúcia de Gusmão Freire Facultad de Fisioterapia, Universidad Estatal de Ciencias de la Salud de Alagoas, Maceió, Brasil. https://orcid.org/0000-0002-7638-742X

DOI:

https://doi.org/10.25176/RFMH.v20i1.2447

Keywords:

Chronic obstructive pulmonary disease, Striated muscle, Anthracosis, Tobacco Use Disorder, Autopsy

Abstract

Introduction: In chronic obstructive pulmonary disease (COPD), the diaphragm and sternocleidomastoid respiratory muscles (ECOM) work against increased mechanical loads due to limited air flow and changes in chest conformation due to the condition of pulmonary hyperinflation. Objective: To evaluate the histopathological changes present in the lungs and respiratory muscles (diaphragm and ECOM) of the corpses affected by COPD. Materials and methods: This is a blind and descriptive study with analysis of histological images of biopsy. The history of smoking associated with the presence of pulmonary anthracosis, septal thickening and emphysematous bullae included the inclusion criteria of the study. The study was conducted by optical microscopic analysis of histological sheets obtained from 36 corpses with COPD. The histopathological diagnosis was made by a pathologist who did not know the objectives of the study. Results: In the diaphragm, there was the presence of interposed adipose tissue, muscle atrophy, removal of muscle fibers and fibrosis. In ECOM, the elimination of muscle fibers, muscular atrophy, interposed adipose tissue, muscle hypertrophy and thickening of the tendons were also evident. Conclusions: The changes found in the diaphragm and ECOM muscle biopsies of the bodies with COPD were evidenced as a mechanism of compensation and / or dysfunction of the respiratory system due to biomechanical alterations promoted by the disease.

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Author Biographies

Tales Lyra de Oliveira, 1) Facultad de Medicina, Universidad Municipal de São Caetano del Sur, São Paulo, Brasil. 2) Unidad de Hipertensión, Instituto del Corazón, Facultad de Medicina, Universidad de Sao Paulo, São Paulo, Brasil.

Fisioterapeuta, Doctor en Ciencias

Tacio Nertan Cartaxo de Souza, Instituto de Ciencias Biológicas y de la Salud, Universidad Federal de Alagoas, Maceió, Brasil.

Fisioterapeuta, Magíster en Ciencias de la Salud.

Byron Martins Lucena, Municipalidad de Maceió, Maceió, Brasil.

Fisioterapeuta

Fernanda Mayara Santos Santana, Facultad de Medicina, Universidad Federal de Alagoas, Maceió, Brasil.

Fisioterapeuta, Estudiante de Medicina.

Lysien Ivania Zambrano, Departamento de Ciencias Morfológicas, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.

Médico Cirujano, Magíster en Ciencias.

Ana Rose de Carvalho Araujo, Facultad de Fisioterapia, Universidad Estatal de Ciencias de la Salud de Alagoas, Maceió, Brasil.

Fisioterapeuta, Magíster en Fisioterapia.

Ana Lúcia de Gusmão Freire, Facultad de Fisioterapia, Universidad Estatal de Ciencias de la Salud de Alagoas, Maceió, Brasil.

Fisioterapeuta, Magíster en Fisioterapia.

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