El difícil camino de los péptidos natriuréticos en la insuficiencia cardiaca: The difficult pathway of natriuretic peptides in heart failure

Omar Augusto Diaz Cucho

doi:10.25176/RFMH.v23i3.5089

Authors

Omar Augusto Diaz Cucho Hospital Alberto Barton Thompson, Callao, Perú

DOI:

https://doi.org/10.25176/RFMH.v23i3.5089

Keywords:

Heart failure, natriuretic peptides, sacubitril-valsartan, neprilysin

Abstract

This review is carried out on the role of natriuretic peptides and attempts to use them properly, as a treatment, their functioning in the pathophysiology of heart failure with depressed systolic function was better understood. It is recounts its journey through multiple failed studies, explaining the reasons for its failures, until it achieved the desired success with the combination of sacubitril/valsartan. This produced a paradigm shift in the management of heart failure.

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Author Biography

Omar Augusto Diaz Cucho, Hospital Alberto Barton Thompson, Callao, Perú

Médico cardiólogo

Máster en Insuficiencia Cardíaca

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