Seguridad y efecto protector de Cenchrus echinatus en el cáncer de mama inducido en ratas: Safety and protective effect of Cenchrus echinatus on breast cancer induced in rats

César B. Cisneros Hilario; Jorge L. Arroyo Acevedo; María P. Bedoya Castillo; Betsy A.  Lázaro Huamán; Katia E. Mendoza Chávez; Evelin J. Cisneros Hilario

doi:10.25176/RFMH.v22i3.4915

Authors

César B. Cisneros Hilario Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú. https://orcid.org/0000-0002-6158-7250
Jorge L. Arroyo Acevedo Facultad de Medicina "San Fernando", Universidad Nacional Mayor de San Marcos, Lima-Perú. https://orcid.org/0000-0002-7695-1908
María P. Bedoya Castillo Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú. https://orcid.org/0000-0002-0485-1350
Betsy A. Lázaro Huamán Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú. https://orcid.org/0000-0003-1330-3409
Katia E. Mendoza Chávez Asociación Peruana de Ciencia, tecnología y medio ambiente saludable. Chimbote - Perú. https://orcid.org/0000-0002-7095-3611
Evelin J. Cisneros Hilario Asociación Peruana de Ciencia, tecnología y medio ambiente saludable. Chimbote - Perú. https://orcid.org/0000-0003-3544-697X

DOI:

https://doi.org/10.25176/RFMH.v22i3.4915

Keywords:

Cenchrus echinatus L., Breast cancer, DMBA

Abstract

Introduction: Breast cancer is a disease that is increasing its incidence annually, so in search of complementary alternatives for treatment have been studied some medicinal plants containing large amounts of polyphenols, which have anticancer effects as is the case of Cenchrus echinatus L.

Objective: To determine the safety and protective effect of ethanol extract of Cenchrus echinatus L. (burdock) on breast cancer induced by 7,12-dimethylbenz[a]anthracene in rats.

Methods: Preclinical, experimental study in male Balb/C53 mice and Holtzman rats of both sexes. Acute toxicity and toxicity at 45 days were calculated using probit and OECD methods, respectively; to evaluate the protective effect, the Barros 2004 method was used; tumor cell proliferation was also registered microscopically, using descriptive and inferential statistical analysis, considering p<0.05.

Results: Safety studies show that the extract does not induce significant hematologic, biochemical and pathological changes level 80% of the protective effect of the extract against DMBA-induced breast cancer in rats was achieved.

Conclusions: It has been shown that Cenchrus echinatus extract L. has protective effect on breast cancer by 7,12-dimethylbenz[a]anthracene induced in rats; and it is not toxic in mice and rats.