Association between hematological parameters and metabolically unhealthy phenotypes in children and adolescents.

Asociación entre parámetros hematológicos y fenotipos metabólicamente poco saludables en niños y adolescentes

Authors

  • GABRIEL JOSE HORTA-BAAS Servicio de Reumatología, Hospital General Regional 1 Instituto Mexicano del Seguro Social
  • PIZANO ZARATE MARIA LUISA Departamento de Nutrición y Bioprogramación Instituto Nacional de Perinatología, Secretaría de Salud
  • JORGE ARTURO NUÑEZ-HERNANDEZ Hospital General Regional 220 Toluca México, Delegación México Poniente Instituto Mexicano del Seguro Social
  • ALVARO JOSE MONTIEL JARQUIN Unidad Médica de Alta Especialidad de Puebla, México, Instituto Mexicano del Seguro Social
  • María del Socorro Romero Figueroa Universidad Anáhuac México, Centro de Investigación en Ciencias de la Salud Lomas Anáhuac 786, Huixquilucan, México; Campus Universitario Siglo XXI, Coordinación de Investigación, Facultad de Medicina

DOI:

https://doi.org/10.25176/RFMH.v23i3.5603

Keywords:

adolescents, children, hematological indices, neutrophils, metabolically unhealthy phenotypes

Abstract

Objective. Metabolic syndrome has been associated with changes in the composition of circulating blood cells. Hematologic indices can be used to identify the subjects at risk of metabolically unhealthy phenotype (MUP). This study investigated whether hematological indices can serve as biomarkers to distinguish metabolically healthy phenotype (MHP) from MUP in children and adolescents.

Methods. Two hundred ninety-two children and adolescents were enrolled in a cross-sectional study. The MUP was diagnosed using consensus-based criteria proposed by Damanhoury et al. Group comparisons were performed using one-way ANOVA. To examine if sex, age group, nutritional status, puberty, hematological parameters, and insulin resistance were associated with MUP, we used multiadjusted logistic regression analysis with metabolic status as the dependent variable. 

 

Results. The subject's age mean was 11 years (SD: 2.61). RDW values were significantly lower in children with metabolically unhealthy normal weight (MUNW) compared to children with metabolically unhealthy obesity (MUO) (12.33 ± 0.90 vs. 13.67 ± 0.52; p = 0.01), and in metabolically healthy obesity (MHO) compared to MUO (13.15 ± 0.53 vs. 13.67 ± 0.52; p = 0.04). In adolescents, the PLR was higher for the MHNW group, with a mean value of 152.60 (SD 62.97) compared to 111.16 (SD 44.12) for the MHO group. After adjusting for age, nutritional status, and puberty, hematological indices were not associated with MUP.

 

Conclusions. The study demonstrates that hematological indices are not independently associated with the metabolically unhealthy phenotype. Hematologic indices are unlikely to represent reliable biomarkers of MU phenotype in the pediatric population.

 

 

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Author Biographies

GABRIEL JOSE HORTA-BAAS, Servicio de Reumatología, Hospital General Regional 1 Instituto Mexicano del Seguro Social

PhD

PIZANO ZARATE MARIA LUISA, Departamento de Nutrición y Bioprogramación Instituto Nacional de Perinatología, Secretaría de Salud

MD

JORGE ARTURO NUÑEZ-HERNANDEZ, Hospital General Regional 220 Toluca México, Delegación México Poniente Instituto Mexicano del Seguro Social

MD

ALVARO JOSE MONTIEL JARQUIN, Unidad Médica de Alta Especialidad de Puebla, México, Instituto Mexicano del Seguro Social

PhD

María del Socorro Romero Figueroa, Universidad Anáhuac México, Centro de Investigación en Ciencias de la Salud Lomas Anáhuac 786, Huixquilucan, México; Campus Universitario Siglo XXI, Coordinación de Investigación, Facultad de Medicina

PhD

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Published

2023-09-14 — Updated on 2023-12-06

How to Cite

Horta-Baas, G. J. ., Pizano Zárate, M. L., Núñez Hernández, J. A., Montiel Jarquín, A. J., & Romero Figueroa, M. del S. (2023). Association between hematological parameters and metabolically unhealthy phenotypes in children and adolescents.: Asociación entre parámetros hematológicos y fenotipos metabólicamente poco saludables en niños y adolescentes. Revista De La Facultad De Medicina Humana, 23(3), 57–67. https://doi.org/10.25176/RFMH.v23i3.5603