Pulmonary Aspergillosis, an approach to clinical and radiological manifestations. Report of three cases

Manifestaciones clínicas y radiológicas de la Aspergilosis Pulmonar: Informe de tres casos

Authors

  • Onaldo José Barrios Taborda Universidad Simón Bolívar. Barranquilla, Colombia.
  • Jhon Edward Valencia Marulanda Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.
  • Luisa Fernanda Sierra Garzón Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.
  • Andrés Alirio Restrepo Bastidas Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.
  • Mateo Aguirre Flórez Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.
  • Ángela María Giraldo Montoya Universidad Tecnológica de Pereira, Universidad de la Sabana. Pereira, Colombia.

DOI:

https://doi.org/10.25176/RFMH.v24i2.6098

Keywords:

Aspergillosis Pulmonary, Aspergillus, Immunocompromised Host, Voriconazole, Respiratory Tract Infections

Abstract

Pulmonary aspergillosis, caused by the opportunistic fungus Aspergillus, primarily affects immunocompromised individuals. This report presents three cases: An 18-year-old female with acute leukemia developed respiratory distress and bilateral "tree-in-bud" patterns on CT. Despite voriconazole treatment, she succumbed to respiratory failure. A 58-year-old female with diabetes and COPD had dyspnea and hemoptysis. Imaging revealed a cavitated lesion, confirming aspergilloma. Surgery was considered due to active hemoptysis. A 41-year-old female with a history of tuberculosis presented with fever and respiratory symptoms. CT showed cavitated lesions and bronchiectasis, confirming chronic aspergillosis. She responded well to voriconazole. These cases highlight the variability in pulmonary aspergillosis and underscore the importance of timely diagnosis and treatment to improve patient outcomes.

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Author Biographies

Onaldo José Barrios Taborda, Universidad Simón Bolívar. Barranquilla, Colombia.

Estudiante de Posgrado en Medicina Interna

Jhon Edward Valencia Marulanda, Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.

Miembro del Grupo de Investigación de Medicina Crítica y Cuidados Intensivos

Luisa Fernanda Sierra Garzón, Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.

Miembro del Grupo de Investigación de Medicina Crítica y Cuidados Intensivos

Andrés Alirio Restrepo Bastidas, Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.

Miembro del Grupo de Investigación de Medicina Crítica y Cuidados Intensivos

Mateo Aguirre Flórez, Grupo Investigación de Medicina Crítica y Cuidados Intensivos GIMCCI, Universidad Tecnológica de Pereira. Pereira, Colombia.

Miembro del Grupo de Investigación de Medicina Crítica y Cuidados Intensivos

Ángela María Giraldo Montoya, Universidad Tecnológica de Pereira, Universidad de la Sabana. Pereira, Colombia.

Internista, Neumóloga

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Published

2024-05-13

How to Cite

Barrios Taborda, O. J. ., Valencia Marulanda, J. E. ., Sierra Garzón, L. F. ., Restrepo Bastidas, A. A., Aguirre Flórez, M., & Giraldo Montoya, Ángela M. . (2024). Pulmonary Aspergillosis, an approach to clinical and radiological manifestations. Report of three cases: Manifestaciones clínicas y radiológicas de la Aspergilosis Pulmonar: Informe de tres casos. Revista De La Facultad De Medicina Humana, 24(2), 166–171. https://doi.org/10.25176/RFMH.v24i2.6098

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