Efecto de la Averrhoa carambola L. en la piel en un modelo animal de cicatrización hipertrófica: Effect of Averrhoa carambola L. on the Skin in an Animal Model of Hypertrophic Scarring

Alberto Córdova-Aguilar; Elydia  Mujica-Albán; José Manuel Ortiz-Sánchez; Silvia Suárez-Cunza; Rodrigo   Iglesias-Bustamante; Daniel José Blanco-Victorio

doi:10.25176/RFMH.v24i3.6538

Authors

Alberto Córdova-Aguilar Faculty of Medicine, National University of San Marcos, Lima-Peru
Elydia Mujica-Albán Faculty of Medicine, National University of San Marcos, Lima, Peru.
José Manuel Ortiz-Sánchez Faculty of Medicine, National University of San Marcos, Lima, Peru.
Silvia Suárez-Cunza Faculty of Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru.
Rodrigo Iglesias-Bustamante Faculty of Veterinary Medicine, National University of San Marcos, Lima, Peru.
Daniel José Blanco-Victorio Faculty of Science and Engineering, Cayetano Heredia University, Lima, Peru.

DOI:

https://doi.org/10.25176/RFMH.v24i3.6538

Keywords:

Averrhoa carambola L, triamcinolone, hypertrophic scar, animal models

Abstract

Introduction: Hypertrophic scarring in the skin represents a serious global public health problem, as it physically and emotionally affects people who suffer from it. This makes it necessary to investigate new alternatives for its prevention and treatment. The objective of the study was to compare the effect of Averrhoa carambola L. (star fruit) on the skin under an animal model of hypertrophic healing. Methods: Experimental study; 10 male New Zealand breed rabbits were used, between 3 and 4 months old, with an average weight of 3 to 3.5Kg. The creation of hypertrophic scars in the ears of rabbits was induced under the model described by Morris et al. One of the groups received 1 mL of a 10% aqueous solution of the lyophilized star fruit, while the other received 1 mL of triamcinolone acetate; in both groups the application was intralesional and weekly in a month. After the treatment, under sedation, only the hypertrophic scars were extracted using a biopsy punch and the tissues were preserved in 10% formalin for subsequent pathological examination. Results: The group that received star fruit solution significantly improved the dermis and epidermis in the hypertrophic scars on the ears of rabbits that received treatment. When compared with the group that received triamcinolone acetonide, there were no statistically significant differences. Conclusion: The lyophilized aqueous extract of star fruit at 10% demonstrated a similar effect compare to triamcinolone acetonide (treatment of choice) in reducing the fibrosis of hypertrophic scars in the ears of rabbits.

Keywords: Averrhoa carambola L., triamcinolone, hypertrophic scar, animal models. (MeSH/NLM)

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Author Biographies

Alberto Córdova-Aguilar, Faculty of Medicine, National University of San Marcos, Lima-Peru

Medical Doctor.

Doctor of Science with a specialization in Physiology.

Surgeon specialized in Plastic Surgery.

Elydia Mujica-Albán, Faculty of Medicine, National University of San Marcos, Lima, Peru.

Doctor of Science with a specialization in Physiology.

Master of Physiology.

Specialist in Plastic Surgery.

José Manuel Ortiz-Sánchez, Faculty of Medicine, National University of San Marcos, Lima, Peru.

Doctor of Medicine.
Master of Physiology.
Specialist in Pathological Anatomy and Clinical Pathology.

Silvia Suárez-Cunza, Faculty of Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru.

Doctor of Pharmacy and Biochemistry.
Master of Physiology.

Rodrigo Iglesias-Bustamante, Faculty of Veterinary Medicine, National University of San Marcos, Lima, Peru.

Doctor of Veterinary Medicine.

Daniel José Blanco-Victorio, Faculty of Science and Engineering, Cayetano Heredia University, Lima, Peru.

Master in Health Management.
Research Specialist.

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Effect of Averrhoa carambola L. on the Skin in an Animal Model of Hypertrophic Scarring