Adenomiomatosis vesicular como hallazgo incidental: reporte de siete casos: Gallbladder adenomyomatosis as an incidental finding: A report of seven cases

María del Pilar Pacheco-Saravia; Yadhira Ariana Rosas-Uchupe; Gabriela Jazmín Palomino-Quiñones; Mario Manuel Aymerich-Lau; Gonzalo David Baldeón-Arzapalo; José Alberto Bendezú-Cahua; Nicole Desire Rojas Guerrero; Eugenio Américo Palomino-Portilla

doi:10.25176/RFMH.v2025i1.6577

Authors

María del Pilar Pacheco-Saravia Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Yadhira Ariana Rosas-Uchupe Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Gabriela Jazmín Palomino-Quiñones Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Mario Manuel Aymerich-Lau Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Gonzalo David Baldeón-Arzapalo Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
José Alberto Bendezú-Cahua Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Nicole Desire Rojas Guerrero Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.
Eugenio Américo Palomino-Portilla Instituto de Investigación en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú. Hospital Nacional Edgardo Rebagliati Martins.

DOI:

https://doi.org/10.25176/RFMH.v2025i1.6577

Abstract

Gallbladder adenomyomatosis is a benign lesion, characterized by hyperplasia of the gallbladder epithelium alternating with hypertrophy of the smooth muscle layer, in whose thickness there are epithelial projections that can reach the subserosa/adventitia of the organ, causing thickening of the gallbladder wall and possible confusion with neoplasia. The entity has been detected in 2 to 8% of all cholecystectomies and up to 5% of necropsies. It is usually asymptomatic and when it does generate symptoms, they are usually those of coexisting cholecystitis/cholelithiasis. It is more common in adults and very rarely in the pediatric population. An interesting factor is its probable relationship with gallbladder cancer. We present 7 cases of vesicular adenomyomatosis, one of them with epithelial dysplasia, considered a precursor lesion to cancer.

Keywords: Adenomyomatosis, gallbladder, dysplasia, gallbladder cancer.

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Author Biographies

María del Pilar Pacheco-Saravia, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Yadhira Ariana Rosas-Uchupe, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Gabriela Jazmín Palomino-Quiñones, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Mario Manuel Aymerich-Lau, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Gonzalo David Baldeón-Arzapalo, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

José Alberto Bendezú-Cahua, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Nicole Desire Rojas Guerrero, Facultad de Medicina Humana, Universidad Ricardo Palma. Lima, Perú.

Medical Student

Eugenio Américo Palomino-Portilla, Instituto de Investigación en Ciencias Biomédicas, Universidad Ricardo Palma, Lima, Perú. Hospital Nacional Edgardo Rebagliati Martins.

Pathologist Physician

References

REFERENCIAS

Parolini F, Indolfi G, Magne MG, Salemme M, Cheli M, Boroni G, Alberti D. Adenomyomatosis of the gallbladder in childhood: A systematic review of the literature and an additional case report. World J Clin Pediatr 2016; 5(2): 223-227

Kim JH, Jeong IH, Han JH, et al. Clinical/pathological analysis of gallbladder adenomyomatosis; type and pathogenesis. Hepatogastroenterology 2010;57:420-5.

K.-F. Lee, E.H.Y. Hung, H.H.W. Leung, P.B.S. Lai, A narrative review of gallbladder adenomyomatosis: what we need to know, Ann. Transl. Med. 8 (2020) 1600, https://doi.org/10.21037/atm-20-4897.

J.K. Joshi, L. Kirk, Adenomyomatosis, in: StatPearls, StatPearls Publishing, Treasure Island (FL), 2021. http://www.ncbi.nlm.nih.gov/books/NBK482244/ (accessed March 10, 2021).

Nishimura A, Shirai Y, Hatakeyama K. Segmental adenomyomatosis of the gallbladder predisposes to cholecystolithiasis.J Hepatobiliary Pancreat Surg 2004;11:342—7.

Jutras JA. Hyperplastic cholecystoses; Hickey lecture, 1960. Am J Roentgenol Radium Ther Nucl Med 1960;83:795-827.

Zarate YA, Bosanko KA, Jarasvaraparn C, Vengoechea J, McDonough EM. Description of the first case of adenomyomatosis of the gallbladder in an infant. Case

Rep Pediatr. 2014; 2014:248369.

Henson DE, Schwartz AM, Nsouli H, Albores-Saavedra J. Carcinomas of the pancreas, gallbladder, extrahepatic bile ducts, and ampulla of vater share a field for carcinogenesis: a population-based study. Arch Pathol Lab Med 2009;133:67-71.

Aldridge MC, Gruffaz F, Castaing D, Bismuth H. Adenomyomatosis of the gallbladder: A premalignant lesion? Surgery 1991; 109: 107–110.

M. Akcam, I. Buyukyavuz, M. C¸ iris¸, and N. Eris¸, “Adenomyomatosis of the gallbladder resembling honeycomb in a child,” European Journal of Pediatrics, vol. 167, no. 9, pp. 1079–1081, 2008.

Nabatame N, Shirai Y, Nishimura A, Yokoyama N, Wakai T, Hatakeyama K. High risk of gallbladder carcinoma and segmental type of adenomyomatosis of the gallbladder. J Exp Clin Cancer Res 2004; 23: 593–598.

Yoshimitsu K, Honda H, Aibe H, Shinozaki K, Kuroiwa T, Irie H, Asayama Y, Masuda K. Radiologic diagnosis of adenomyomatosis of the gallbladder: comparative study among MRI, helical CT, and transabdominal US. J Comput Assist Tomogr 2001; 25: 843-850 [PMID: 11711793]

Pellino G, Sciaudone G, Candilio G, Perna G, Santoriello A, Canonico S, Selvaggi F. Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review. Hepatobiliary Pancreat Dis Int 2013; 12: 136-142 [PMID: 23558066 DOI: 10.1016/ S1499-3872(13)60022-3]

Charles H, Pilgrim C, Groeschl RT, et al. Modern perspective on factors predisposing to the development of gallbladder cancer. HPB. 2013;15:839–844.

Stunell H, Buckley O, Geoghegan T, O’Brien J, Ward E, Torreggiani W. Imaging f adenomyomatosis of the gallbladder. J Med Imaging Radiat Oncol 2008; 522: 109–117)

Gallbladder adenomyomatosis as an incidental finding: A report of seven cases