Dengue infection in a patient with systemic lupus erythematosus: a case report
Infección por dengue en un paciente con lupus eritematoso sistémico: reporte de caso
DOI:
https://doi.org/10.25176/RFMH.v24i4.6519Keywords:
Systemic Lupus Erythematosus, Cutaneous Lupus Erythematosus, Dengue, Viral Zoonoses, FeverAbstract
Systemic Lupus Erythematosus (SLE) is an autoimmune disease caused by an autoreactive B and T cell response with loss of immune tolerance to self-antigens. It manifests with asthenia, fever, myalgias, arthralgias, skin rash and fatal organ damage. Dengue is a zoonotic disease caused by the dengue virus (DENV), transmitted by mosquitoes of the Aedes aegypti species. Diagnostic suspicion is made in the presence of acute febrile syndrome with clinical manifestations and demographic history. Confirmation is by detection of the virus by PCR-RT, or of the structural protein NS1. The present case report is a 58-year-old woman with data of lupus exacerbation and with clinical manifestations suggestive of Dengue fever, with a history of travel to an endemic area. The confirmatory PCR-RT test leads to appropriate medical treatment. The importance of the case lies in differentiating the diagnosis in a timely manner.
Downloads
References
Kiriakidou M, Ching CL. Systemic Lupus Erythematosus. Ann Intern Med.
Jun 2;172(11):ITC81-ITC96. doi: 10.7326/AITC202006020. PMID:
Harapan H, Michie A, Sasmono RT, Imrie A. Dengue: A Minireview. Viruses.
Jul 30;12(8):829. doi: 10.3390/v12080829. PMID: 32751561; PMCID:
PMC7472303.
Rees F, Doherty M, Grainge MJ, Lanyon P, Zhang W. The worldwide
incidence and prevalence of systemic lupus erythematosus: a systematic
review of epidemiological studies. Rheumatology (Oxford). 2017 Nov
;56(11):1945-1961. doi: 10.1093/rheumatology/kex260. PMID: 28968809.
Wallace JD, Gladman Dafna D. Clinical manifestations and diagnosis of
systemic lupus in adults. UpToDate [Internet]. Uptodate.com. [citado el 9 de
abril de 2024]. Disponible en: https://www.uptodate.com/contents/clinical-
manifestations-and-diagnosis-of-systemic-lupus-erythematosus-in-adults
Aringer M, Costenbader K, Daikh D, Brinks R, Mosca M, Ramsey-Goldman
R, Smolen JS, et al. 2019 European League Against Rheumatism/American
College of Rheumatology Classification Criteria for Systemic Lupus
Erythematosus. Arthritis Rheumatol. 2019 Sep;71(9):1400-1412. doi:
1002/art.40930. Epub 2019 Aug 6. PMID: 31385462; PMCID:
PMC6827566.
Sifuentes Giraldo WA, García Villanueva MJ, Boteanu AL, Lois Iglesias A,
Zea Mendoza AC. New therapeutic targets in systemic lupus. Reumatol
Clin. 2012 Jul-Aug;8(4):201-7. English, Spanish. doi:
1016/j.reuma.2012.01.012. Epub 2012 Apr 6. PMID: 22483661.
Panorama Epidemiológico de Fiebre por Dengue y Fiebre Hemorrágica por
Dengue con información del Sistema Especial de Vigilancia Epidemiológica
de Dengue. Publicación por Semana Epidemiológica a cargo de la
Dirección de Vigilancia Epidemiológica de Enfermedades Transmisibles.
Semana Epidemiológica 52. Gob.mx. [citado el 05 de enero de 2023].
Disponible en:
https://www.gob.mx/cms/uploads/attachment/file/878786/Pano_dengue_52_
Frantchez V., Fornelli R., Graciela Pérez S., Arteta Z., Cabrera S., Sosa., et
al. Dengue en adultos: diagnóstico, tratamiento y abordaje de situaciones
especiales. Rev. Méd. Urug. [Internet]. 2016 Abr [citado 2023 Mar 23];
(1): 43-51. Disponible en:
http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-
&lng=es.
Aringer M, Costenbader K, Johnson SR. Evaluación de los criterios de
clasificación EULAR/ACR para pacientes con lupus eritematoso sistémico.
Experto Rev Clin Immunol. 2022 febrero; 18 (2):135-144.
Dima A, Jurcut C, Chasset F, Felten R, Arnaud L. Hydroxychloroquine in
systemic lupus erythematosus: overview of current knowledge. Ther Adv
Musculoskelet Dis.2022;14:1759720X211073001.
Muller DA, Depelsenaire AC, Young PR. Clinical and Laboratory Diagnosis
of Dengue Virus Infection. J Infect Dis. 2017 Mar 1;215(suppl_2):S89-S95.
doi: 10.1093/infdis/jiw649. PMID: 28403441.
Guzman MG, Harris E. Dengue. Lancet. 2015 Jan 31;385(9966):453-65.
doi: 10.1016/S0140-6736(14)60572-9. Epub 2014 Sep 14. PMID:
Medina F, Medina JF, Colón C, Vergne E, Santiago GA, Muñoz-Jordán JL.
Dengue virus: isolation, propagation, quantification, and storage. Curr
Protoc Microbiol. 2012 Nov;Chapter 15:Unit 15D.2.. doi:
1002/9780471729259.mc15d02s27. PMID: 23184594.
Soo KM, Khalid B, Ching SM, Chee HY. Meta-Analysis of Dengue Severity
during Infection by Different Dengue Virus Serotypes in Primary and
Secondary Infections. PLoS One. 2016 May 23;11(5):e0154760. doi:
1371/journal.pone.0154760. PMID: 27213782; PMCID: PMC4877104.
Vera-Rivero DA, Chirino-Sánchez L, Martínez Lastre A, Medición de la
actividad lúpica y daño acumulado en pacientes con lupus eritematoso
sistémico. Rev Cuba Reumatol [Internet]. 2019 Ago [citado 2024 Abr 09]; 21
(2): e88. Disponible en:
http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1817-
&lng=es.
Grande AJ, Reid H, Thomas E, Foster C, Darton TC. Tourniquet Test for
Dengue Diagnosis: Systematic Review and Meta-analysis of Diagnostic
Test Accuracy. PLoS Negl Trop Dis. 2016 Aug 3;10(8):e0004888. doi:
1371/journal.pntd.0004888. PMID: 27486661; PMCID: PMC4972435.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Revista de la Facultad de Medicina Humana
This work is licensed under a Creative Commons Attribution 4.0 International License.