Evolución de la terapia fotodinámica en el manejo de la queratosis actínica ¿qué tan efectiva y segura es según la evidencia actual? Evolution of photodynamic therapy in the management of actinic keratosis: how effective and safe is it according to current evidence?

Laura Valentina  Vargas-Monroy; Andrés Felipe  Londoño-Serna; Duvan Alejandro  Grisales-Cano; Carlos Andrés  Jaraba-Herazo; Ivan Andres  Peña-Chamorro; Max Jesus  Bustillo-Orozco; Zulmy Valeria  Montenegro-Salcedo; Michael Ortega-Sierra

doi:10.25176/RFMH.v24i4.6016

Authors

Laura Valentina Vargas-Monroy Universidad Nacional de Colombia
Andrés Felipe Londoño-Serna Remington University Corporation
Duvan Alejandro Grisales-Cano Cooperative University of Colombia
Carlos Andrés Jaraba-Herazo University of Applied and Environmental Sciences
Ivan Andres Peña-Chamorro University of Cartagena
Max Jesus Bustillo-Orozco University of the North
Zulmy Valeria Montenegro-Salcedo University of Cauca
Michael Ortega-Sierra Universidad Centroccidental Lisandro Alvarado

DOI:

https://doi.org/10.25176/RFMH.v24i4.6016

Keywords:

Phototherapy, Actinic Keratosis, Therapeutics, Safety, Efficacy

Abstract

Actinic keratosis is a premalignant dermatological condition characterized by the potential to progress to squamous cell carcinoma. To date, there is no treatment with an adequate benefit-risk balance. Photodynamic therapy is proposed as one of the most effective therapeutic tools. However, there is still divergence regarding the quality of available evidence. The objective of this review is to analyze the most recent evidence on the therapeutic performance of photodynamic therapy in the management of actinic keratosis. A literature search was conducted in the PubMed, Scopus, and MEDLINE databases. Based on the most recent randomized controlled trial comparing the use of dynamic phototherapy combined with aminolevulinic acid without incubation versus incubation for one hour, it was found that the intervention group had a higher percentage of lesion resolution compared to the control group (49.5% vs. 34.9%, p=0.002), as well as less pain in the intervention group (p=0.03). In addition, a similar trend was observed in other studies, suggesting that this therapy could be effective and beneficial in the management of actinic keratosis. Despite the limited and heterogeneous evidence regarding the use of dynamic phototherapy and its various combined regimens for the management of actinic keratosis, there is a clear trend towards potential benefits compared to other therapies.

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Author Biographies

Laura Valentina Vargas-Monroy, Universidad Nacional de Colombia

General Physician

Andrés Felipe Londoño-Serna, Remington University Corporation

General Physician

Duvan Alejandro Grisales-Cano, Cooperative University of Colombia

General Physician

Carlos Andrés Jaraba-Herazo, University of Applied and Environmental Sciences

General Physician

Ivan Andres Peña-Chamorro , University of Cartagena

General Physician

Max Jesus Bustillo-Orozco, University of the North

General Physician

Zulmy Valeria Montenegro-Salcedo, University of Cauca

General Physician

Michael Ortega-Sierra, Universidad Centroccidental Lisandro Alvarado

General Physician

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