MODELOS MURINOS PARA EL ESTUDIO DE CÁNCER DE MAMA TRIPLE NEGATIVO
MURINE MODELS FOR THE STUDY OF TRIPLE NEGATIVE BREAST CANCER
DOI:
https://doi.org/10.25176/RFMH.v23i4.6206Palabras clave:
modelo murino, cancer de mama triple negativo, inducción, terapia antitumoralResumen
RESUMEN
El estudio de diferentes variables, como patogénesis, perfil inflamatorio, identificación de blancos terapéuticos, eficacia de tratamientos en modelos murinos ha resultado uno de los más prácticos para el estudio preclínico del cáncer de mama triple negativo (CMTN), el subtipo de cáncer más agresivo, con limitada aplicación de tratamientos y baja tasa de sobrevivencia. Sin embargo, hay que reconocer que existen otros menores en los que se viene estandarizando la inducción del CMTN. En esta revisión se engloban los diferentes métodos de inducción que han permitido el desarrollo de CMTN y las aplicaciones terapéuticas más relevantes por el que se desarrollaron los modelos murinos con CMTN.
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