Deficiencia vitamina B1,B6,B12, Vitaminas B1, B6, B12 y Neuropatías Periféricas. Revisión sistemática de la literatura.
Vitamins B1, B6, and B12 and Peripheral Neuropathies: A Systematic Review of the Literature. | 周围神经病、维生素B1、B6和B12：文献系统综述
DOI:
https://doi.org/10.25176/RFMH.v24i3.6686Palabras clave:
Deficiencia vitamina B1, vitamina B6, vitamina B12, neuropatía periférica, revisión sistemáticaResumen
Bajo el término neuropatía periférica se agrupan condiciones muy variadas y complejas que presentan dificultades para su abordaje diagnóstico y terapéutico. Uno de los factores que se encuentran en la base de esas entidades es el déficit de las vitaminas neurotróficas B1, B6 y B12.
Dado los extremos oscuros o mal conocidos de este asunto y el empirismo con el que se han utilizado los recursos terapéuticos, se ha realizado una búsqueda exhaustiva de la literatura intentando ordenar y basar en evidencia científica las ideas y puntos conflictivos que han presidido la aproximación al tema por parte de los profesionales concernidos por él.
Este estudio sirve de base a un intento de consenso de expertos que promueva una serie de
recomendaciones que racionalicen y faciliten el manejo del tema en la práctica clínica.
Descargas
Citas
Hanewinckel R, van Oijen M, Ikram MA, van Doorn PA. The epidemiology and risk factors of chronic polyneuropathy. Eur J Epidemiol. 2016 Jan;31(1):5-20. doi: 10.1007/s10654-015-0094-6.
Doughty CT, Seyedsadjadi R. Approach to Peripheral Neuropathy for the Primary Care Clinician. Am J Med. 2018 Sep;131(9):1010-1016. doi: 10.1016/j.amjmed.2017.12.042.
Hicks CV, Wang F, Windham BG, Matsushita K, Selvin E. Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts. Scientific Reports 2021 Sept;11(1):19159. doi: 10.1038/s41598-021-98565-w.
Karedath J, Batool S, Arshad A, Khalique S, Raja S, Lal B, Anirudh Chunchu V, Hirani S. The Impact of Vitamin B12 Supplementation on Clinical Outcomes in Patients With Diabetic Neuropathy: A Meta-Analysis of Randomized Controlled Trials. Cureus. 2022 Nov 22;14(11):e31783. doi: 10.7759/cureus.31783.
Watson JC, Dyck PJ. Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management. Mayo Clin Proc. 2015 Jul;90(7):940-951. doi: 10.1016/j.mayocp.2015.05.004.
Ziegler D, Rathmann W, Dickhaus T, Meisinger C, Mielck A; KORA Study Group. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3. Pain Med. 2009 Mar;10(2):393-400. doi: 10.1111/j.1526-4637.2008.00555.x.
Ziegler D, Papanas N, Vinik AI, Shaw JE. Epidemiology of polyneuropathy in diabetes and prediabetes. Handb Clin Neurol. 2014;126:3-22. doi: 10.1016/B978-0-444-53480-4.00001-1.
Thornalley PJ, Babaei-Jadidi R, Al Ali H, Rabbani N, Antonysunil A, Larkin J, Ahmed A, Rayman G, Bodmer CW. High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia. 2007 Oct;50(10):2164-70. doi: 10.1007/s00125-007-0771-4.
Alvarez M, Sierra OR, Saavedra G, Moreno S. Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: a cross-sectional study. Endocr Connect. 2019 Oct 1;8(10):1324-1329. doi: 10.1530/EC-19-0382.
Beulens JW, Hart HE, Kuijs R, Kooijman-Buiting AM, Rutten GE. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol. 2015 Feb;52(1):47-53. doi: 10.1007/s00592-014-0597-8.
Chapman LE, Darling AL, Brown JE. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab. 2016 Nov;42(5):316-327. doi: 10.1016/j.diabet.2016.03.008.
Kakarlapudi Y, Kondabolu SK, Tehseen Z, Khemani V, J SK, Nousherwani MD, Saleem F, Abdelhameed AN. Effect of Metformin on Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus and Factors Associated With It: A Meta-Analysis. Cureus. 2022 Dec 7;14(12):e32277. doi: 10.7759/cureus.32277.
Niafar M, Hai F, Porhomayon J, Nader ND. The role of metformin on vitamin B12 deficiency: a meta-analysis review. Intern Emerg Med. 2015 Feb;10(1):93-102. doi: 10.1007/s11739-014-1157-5.
Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr. Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2012 Feb;35(2):327-333. doi: 10.2337/dc11-1582.
Castelli G, Desai KM, Cantone RE. Peripheral Neuropathy: Evaluation and Differential Diagnosis. Am Fam Physician. 2020 Dec 15;102(12):732-739. PMID: 33320513.
Imbachí-Salamanca AJ, Chito-Castro KL, Orozco-Burbano JD, Zamora-Bastidas TO. Neuropatías periféricas, un enfoque multidimensional y práctico de una compleja condición. Rev CES Med. 2022;36(1):46-58. https://dx.doi.org/10.21615/cesmedicina.6250.
McCaddon A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013;95: 1066-1076. doi: 10.1016/j.biochi.2012.11.017.
Riccò M, Rapacchi C, Romboli A, Vezzosi L, Rubichi F, Petracca GL, Ferrari S, Valente M, Tartamella F, Marchesi F. Peripheral neuropathies after bariatric surgery. Preliminary results from a single-centre prospective study in Northern Italy. Acta Biomed. 2019 Sep 6;90(3):259-265. doi: 10.23750/abm.v90i3.7601.
Calderón-Ospina CA, Franco-González H, Leal-Martínez F, Orozco-Vázquez H, Plascencia-Pérez S, Sánchez-Mijangos J. Uso clínico de las vitaminas B neurotrópicas en enfermedades del sistema nervioso periférico en México y América Central. Med Int Mex. 2022;38:887-902. doi: 10.24245/mim.v38i4.5133.
Calderón-Ospina CA, Palacios-Sánchez L, Nava-Mesa MO, Huertas-Quintero JA. Vitaminas B neurotrópicas y neuropatía periférica: estado del arte y acuerdo de expertos. Acta Neurol Colomb. 2023;39(4):1201. doi: 10.22379/anc.v39i4.1201.
Julian T, Syeed R, Glascow N, Angelopoulou E, Zis P. B12 as a Treatment for Peripheral Neuropathic Pain: A Systematic Review. Nutrients. 2020 Jul 25;12(8):2221. doi: 10.3390/nu12082221. PMID: 32722436; PMCID: PMC7468922.
Stein J, Geisel J, Obeid R. Association between neuropathy and B-vitamins: A systematic review and meta-analysis. Eur J Neurol. 2021 Jun;28(6):2054-2064. doi: 10.1111/ene.14786.
Leishear K, Boudreau RM, Studenski SA, Ferrucci L, Rosano C, de Rekeneire N, Houston DK, Kritchevsky SB, Schwartz AV, Vinik AI, Hogervorst E, Yaffe K, Harris TB, Newman AB, Strotmeyer ES; Health, Aging and Body Composition Study. Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults. J Am Geriatr Soc. 2012 Jun;60(6):1057-1063. doi: 10.1111/j.1532-5415.2012.03998.x.
Isenberg-Grzeda E, Kutner HE, Nicolson SE. Wernicke-Korsakoff-Syndrome: Under-Recognized and Under-Treated. J. Psychosom. Res. 2012;53:507-516. doi: 10.1016/j.psym.2012.04.008.
Coughlin CR 2nd, Tseng LA, Abdenur JE, Ashmore C, Boemer F, Bok LA, Boyer M, Buhas D, Clayton PT, Das A, Dekker H, Evangeliou A, Feillet F, Footitt EJ, Gospe SM Jr, Hartmann H, Kara M, Kristensen E, Lee J, Lilje R, Longo N, Lunsing RJ, Mills P, Papadopoulou MT, Pearl PL, Piazzon F, Plecko B, Saini AG, Santra S, Sjarif DR, Stockler-Ipsiroglu S, Striano P, Van Hove JLK, Verhoeven-Duif NM, Wijburg FA, Zuberi SM, van Karnebeek CDM. Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency. J Inherit Metab Dis. 2021 Jan;44(1):178-192. doi: 10.1002/jimd.12332.
Morris MS, Picciano MF, Jacques PF, Selhub J. Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr. 2008 May;87(5):1446-1454. doi: 10.1093/ajcn/87.5.1446.
Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr. 1994;60(1):2.
Solomon LR. Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress. Eur J Clin Nutr. 2015 Jun;69(6):687-92. doi: 10.1038/ejcn.2014.272.
Dyck PJ, Albers JW, Andersen H, Arezzo JC, Biessels GJ, Bril V, Feldman EL, Litchy WJ, O'Brien PC, Russell JW; Toronto Expert Panel on Diabetic Neuropathy. Diabetic polyneuropathies: update on research definition, diagnostic criteria and estimation of severity. Diabetes Metab Res Rev. 2011 Oct;27(7):620-628. doi: 10.1002/dmrr.1226.
Russell JW, Zilliox LA. Diabetic neuropathies. Continuum (Minneap Minn). 2014 Oct;20(5 Peripheral Nervous System Disorders):1226-1140. doi: 10.1212/01.CON.0000455884.29545.d2.
Hin H, Clarke R, Sherliker P, Atoyebi W, Emmens K, Birks J, Schneede J, Ueland PM, Nexo E, Scott J, Molloy A, Donaghy M, Frost C, Evans JG. Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study. Age Ageing. 2006 Jul;35(4):416-422. doi: 10.1093/ageing/afl033.
Calderon-Ospina CA, Nava-Mesa MO. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2020;26:5-13. doi: 10.1111/cns.13207.
Hakim M, Kurniani N, Pinzon RT, Tugasworo D, Basuki M, Haddani H, et al. Management of peripheral neuropathy symptoms with a fixed dose combination of high-dose vitamin B1, B6 and B12: A 12-week prospective noninterventional study in Indonesia. Asian J Med Sci. 2018; 9:32-40. doi: 10.3126/ajms.v9i1.18510.
Didangelos T, Karlafti E, Kotzakioulafi E, Margariti E, Giannoulaki P, Batanis G, Tesfaye S, Kantartzis K. Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-controlled Trial. Nutrients. 2021 Jan 27;13(2):395. doi: 10.3390/nu13020395.
Liew J, Barlow A, Lim L-L, Suastika K, Yasahardja Y, Chan SP, Soh A, Li LS, Tan AT; 2244-PUB: Role of B Vitamins (B1, B6, B12) in Managing Diabetic Peripheral Neuropathy (DPN): A Systematic Review. Diabetes 1 June 2019; 68 (Supplement_1):2244–PUB. https://doi.org/10.2337/db19-2244-PUB.
Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005 Jun;14(2):48-54. PMID: 16008162.
Karedath J, Batool S, Arshad A, Khalique S, Raja S, Lal B, Anirudh Chunchu V, Hirani S. The Impact of Vitamin B12 Supplementation on Clinical Outcomes in Patients With Diabetic Neuropathy: A Meta-Analysis of Randomized Controlled Trials. Cureus. 2022 Nov 22;14(11):e31783. doi: 10.7759/cureus.31783.
Fonseca VA, Lavery LA, Thethi TK, Daoud Y, DeSouza C, Ovalle F, Denham DS, Bottiglieri T, Sheehan P, Rosenstock J. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med. 2013 Feb;126(2):141-149. doi: 10.1016/j.amjmed.2012.06.022.
Jaya MK, Dwicandra NM. Effectivity analysis of neuroprotector (vitamin B complex and mecobalamin) as neuropathic pain supportive therapy in elderly with type 2 diabetes mellitus. Asian J Pharm Clin Res. 2017;10:320-323. doi: 10.22159/ajpcr.2017.v10i12.21845
Vollbracht C, Gündling PW, Kraft K, Friesecke I. Blood concentrations of vitamins B1, B6, B12, C and D and folate in palliative care patients: Results of a cross-sectional study. J Int Med Res. 2019 Dec;47(12):6192-6205. doi: 10.1177/0300060519875370.
Clarke R, Grimley Evans J, Schneede J, Nexo E, Bates C, Fletcher A, Prentice A, Johnston C, Ueland PM, Refsum H, Sherliker P, Birks J, Whitlock G, Breeze E, Scott JM. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004 Jan;33(1):34-41. doi: 10.1093/ageing/afg109.
Institute of Medicine. Dietary Reference Intakes: thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington (DC): National Academies Press; 2000.
Bailey RL, Carmel R, Green R, Pfeiffer CM, Cogswell ME, Osterloh JD, Sempos CT, Yetley EA. Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr. 2011 Aug;94(2):552-61. doi: 10.3945/ajcn.111.015222.
Vargas-Uricoechea H, Nogueira JP, Pinzón-Fernández MV, Agredo-Delgado V, Vargas-Sierra HD. Population Status of Vitamin B12 Values in the General Population and in Individuals with Type 2 Diabetes, in Southwestern Colombia. Nutrients. 2023; 15(10):2357. https://doi.org/10.3390/nu15102357.
Kato N, Narita Y, Kamohara S. Liver vitamin B 12 levels in chronic liver diseases. J Vitaminol (Kyoto). 1959 Jun 10;5:134-40. doi: 10.5925/jnsv1954.5.134. PMID: 14404737.
Ståhlberg KG, Radner S, Nordén A. Liver B12 in subjects with and without vitamin B12 deficiency. A quantitative and qualitative study. Scand J Haematol. 1967;4(4):312-30. doi: 10.1111/j.1600-0609.1967.tb01632.x. PMID: 6078062.
Bozian RC, Ferguson JL, Heyssel RM, Meneely GR, Darby WJ. Evidence concerning the human requirement for vitamin B12. Use of the whole body counter for determination of absorption of vitamin B12. Am J Clin Nutr. 1963 Feb;12:117-29. doi: 10.1093/ajcn/12.2.117. PMID: 14014759.
Amin S, Spinks T, Ranicar A, Short MD, Hoffbrand AV. Long-term clearance of [57Co]cyanocobalamin in vegans and pernicious anaemia. Clin Sci (Lond). 1980 Jan;58(1):101-3. doi: 10.1042/cs0580101. PMID: 6766367.
Boddy K, Adams JF. The long-term relationship between serum vitamin B12 and total body vitamin B12. Am J Clin Nutr. 1972 Apr;25(4):395-400. doi: 10.1093/ajcn/25.4.395. PMID: 4622019.
Reizenstein P, Ek G, Matthews CM. Vitamin B-12 kinetics in man. Implications on total-body-B-12-determinations, human requriements, and normal and pathological cellular B12 uptake. Phys Med Biol. 1966 Apr;11(2):295-306. doi: 10.1088/0031-9155/11/2/309. PMID: 5954616.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998. PMID: 23193625.
Chanarin I. 1990. The Megaloblastic Anaemias, 3rd ed. Boston: Blackwell Scientific.
Dinamarca-Montecinos JL, Vásquez-Leiva A. Are older adults with hip fractures a specific risk group for vitamin B12 deficiency? JCSM Clinical Reports 2022;7:44-52. doi: 0.1002/crt2.48.
Vinik A. Diabetic sensory and motor neuropathy. N Enlg J Med. 2016; 374:1455-1464. doi; 10.1056/NEJMcp1503948.
Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Refsum H, Raiten DJ. Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review. J Nutr. 2018 Dec 1;148(suppl_4):1995S-2027S. doi: 10.1093/jn/nxy201.
Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. 2017 Sep 15;96(6):384-389. PMID: 28925645.
Hannibal L, Lysne V, Bjørke-Monsen AL, Behringer S, Grünert SC, Spiekerkoetter U, Jacobsen DW, Blom HJ. Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency. Front Mol Biosci. 2016 Jun 27;3:27. doi: 10.3389/fmolb.2016.00027. Erratum in: Front Mol Biosci. 2017 Aug 08;4:53. PMID: 27446930; PMCID: PMC4921487.
Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017 Jun 29;3:17040. doi: 10.1038/nrdp.2017.40. Erratum in: Nat Rev Dis Primers. 2017 Jul 20;3:17054. PMID: 28660890.
Pinzon RT, Schellack N, Matawaran BJ, Tsang MW, Deerochanawong C, Hiew FL, Nafach J, Khadilkar S. Clinical Recommendations for the use of Neurotrophic B vitamins (B1, B6, B12) for the Management for Peripheral Neuropathy: Consensus from a Multidisciplinary Expert Panel. J Assoc Physicians India. 2023;71(7):93-98. doi: 10.59556/japi.71.0290.
Hernando-Requejo V. Neurological pathology associated with vitamin B group deficiency: thiamine, folate and cobalamin. Nutr Hosp 2018; 35: 54-59. doi: 10.20960/nh.2289.
Vinik AI, Strotmeyer ES. Diabetic Neuropathy. In Pathy’s Principles and Practice of Geriatric Medicine. Sinclair AJ, Morley JE, Vellas B, eds.; JohnWiley & Sons, Ltd.: Chichester, UK, 2012; pp. 751–767. ISBN 978-1-119-95293-0.
Rodríguez-Gutiérrez R, Montes-Villarreal J, Rodríguez-Velver KV, González-Velázquez C, Salcido-Montenegro A, Elizondo-Plazas A, González-González JG. Metformin Use and Vitamin B12 Deficiency: Untangling the Association. Am J Med Sci. 2017 Aug;354(2):165-171. doi: 10.1016/j.amjms.2017.04.010.
Sánchez H, Masferrer D, Lera L, Arancibia E, Angel B, Albala C. Vitamin B12 deficiency associated with high doses of metformin in older people diabetic. Nutr Hosp. 2014;29:1394‑1400.
American Diabetes Association. 1. Improving Care and Promoting Health in Populations: Standards of Medical Care in Diabetes-2020. Diabetes Care 2020;43:S7-S13. doi: 10.2337/dc20-S001.
Shivaprasad C, Gautham K, Ramdas B, Gopaldatta KS, Nishchitha K. Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus. Acta Diabetol. 2020 Sep;57(9):1073-1080. doi: 10.1007/s00592-020-01526-4.
Serra MC, Kancherla V, Khakharia A, Allen LL, Phillips LS, Rhee MK, Wilson PWF, Vaughan CP. Long-term metformin treatment and risk of peripheral neuropathy in older Veterans. Diabetes Res Clin Pract. 2020 Dec;170:108486. doi: 10.1016/j.diabres.2020.108486.
Ziegler D, Tesfaye S, Spallone V, Gurieva I, Al Kaabi J, Mankovsky B, Martinka E, Radulian G, Nguyen KT, Stirban AO, Tankova T, Varkonyi T, Freeman R, Kempler P, Boulton AJ. Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022;186:109063. doi: 10.1016/j.diabres.2021.109063.
Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D; American Diabetes Association. Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005 Apr;28(4):956-62. doi: 10.2337/diacare.28.4.956.
Botas Velasco M, Cervell Rodríguez D, Rodríguez Montalbán AI, Vicente Jiménez S, Fernández de Valderrama Martínez I. Actualización en el diagnóstico, tratamiento y prevención de la neuropatía diabética periférica. Angiología. 2017;69(3):174-181.
Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3(3):CD004655. doi: 10.1002/14651858.CD004655.pub3. PMID: 29543316; PMCID: PMC6494183.
Andrès E, Henoun Loukili N, Noel E, Maloisel F, Vinzio S, Kaltenbach G, Caro-Sampara F, licklé JF. Effects of oral crystalline cyanocobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in Ten Patients. Curr Ther Res Clin Exp. 2005;66:13-22. doi: 10.1016/j.curtheres.2005.02.001.
Bensky MJ, Ayalon-Dangur I, Ayalon-Dangur R, Naamany E, Gafter-Gvili A, Koren G, Shiber S. Comparison of sublingual vs. intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency. Drug Deliv Transl Res. 2019 Jun;9(3):625-630. doi: 10.1007/s13346-018-00613-
Parry-Strong A, Langdana F, Haeusler S, Weatherall M, Krebs J. Sublingual vitamin B12 compared to intramuscul.ar injection in patients with type 2 diabetes treated with metformin: a randomised trial. N Z Med J. 2016 Jun 10;129(1436):67-75. PMID: 27355231,
Sanz-Cuesta T, González-Escobar P, Riesgo-Fuertes R, Garrido-Elustondo S, del Cura-González I, Martín-Fernán dez J, Escortell-Mayor E, Rodríguez-Salvanés F, García-Solano M, González-González R, Martín-de la Sierra-San Agustín MÁ, Olmedo-Lucerón C, Sevillano Palmero ML, Mateo-Ruiz C, Medina-Bustillo B, Valdivia-Pérez A, García-de Blas-González F, Mariño-Suárez JE, Rodríguez-Barrientos R, Ariza-Cardiel G, Cabello-Ballesteros LM, Polentinos-Castro E, Rico-Blázquez M, Rodríguez-Monje MT, Soto-Díaz S, Martín-Iglesias S, Rodríguez-González R, Bretón-Lesmes I, Vicente-Herrero M, Sánchez-Díaz J, Gómez-Gascón T, Drake-Canela M, Asúnsolo-del Barco Á; OB12 Group. Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12). BMC Public Health. 2012 May 31;12:394. doi: 10.1186/1471-2458-12-394.
Vidal‐Alaball J, Butler C, Cannings‐John R, Goringe A, Hood K, McCaddon A, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev 2005;20:CD004655.
Scott JM. Bioavailability of vitamin B12. Eur J Clin Nutr. 1997 Jan;51 Suppl 1:S49-53. PMID: 9023481.
Elangovan R, Baruteau J. Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation? Front Pharmacol. 2022 Sep 29;13:972468. doi: 10.3389/fphar.2022.972468.
Eussen SJ, de Groot LC, Clarke R, Schneede J, Ueland PM, Hoefnagels WH, van Staveren WA. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med. 2005 May 23;165(10):1167-72. doi: 10.1001/archinte.165.10.1167.
Chawla J, Kvarnberg D. Hydrosoluble vitamins. Handb Clin Neurol. 2014;120:891-914. doi: 10.1016/B978-0-7020-4087-0.00059-0.
Ang CD, Alviar MJ, Dans AL, Bautista-Velez GG, Villaruz-Sulit MV, Tan JJ, Co HU, Bautista MR, Roxas AA. Vitamin B for treating peripheral neuropathy. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD004573. doi: 10.1002/14651858.CD004573.pub3.
Hammond N, Wang Y, Dimachkie MM, Barohn RJ. Nutritional neuropathies. Neurol Clin. 2013 May;31(2):477-489. doi: 10.1016/j.ncl.2013.02.002.
Dieb W, Moreau N, Rochefort J, Bouche Y. Role of vitamin B6 in idiopathic burning mouth syndrome: some clinical observations. Med Buccale Chir Buccale 2017;23:77-83. doi: 10.1051/mbcb/2016038.
Hadtstein F, Vrolijk M. Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity. Adv Nutr. 2021 Oct 1;12(5):1911-1929. doi: 10.1093/advances/nmab033.
O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010 Mar;2(3):299-316. doi: 10.3390/nu2030299.
Wolffenbuttel BHR, Heiner-Fokkema MR, Green R, Gans ROB. Relationship between serum B12 concentrations and mortality: experience in NHANES. BMC Med. 2020 Oct 9;18(1):307. doi: 10.1186/s12916-020-01771-y.
Hughes RA. Peripheral neuropathy. BMJ. 2002 Feb 23;324(7335):466-9. doi: 10.1136/bmj.324.7335.466.
Díaz-Cabezas R, Ruano-Restrepo MI, Chacón-Cardona JA, Vera-González A. Perfil neuroepidemiológico en la zona centro del departamento de Caldas (Colombia), años 2004-2005. Rev Neurol. 2006:646–652.
Pradilla AG, Vesga A. BE, León-Sarmiento FE. Estudio neuroepidemiológico nacional (Epineuro) colombiano. Rev Panam Salud Pública. 2003;14(2):104–111. https://doi.org/10.1590/S1020-49892003000700005.
Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 Jan;40(1):136-154. doi: 10.2337/dc16-2042.
Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep. 2019 Aug 27;19(10):86. doi: 10.1007/s11892-019-1212-8.
Sun J, Wang Y, Zhang X, Zhu S, He H. Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis. Prim Care Diabetes. 2020 Oct;14(5):435-444. https://doi.org/10.1016/j.pcd.2019.12.005.
Yovera-Aldana M, Velásquez-Rimachi V, Huerta-Rosario A, More-Yupanqui MD, Osores-Flores M, Espinoza R, Gil-Olivares F, Quispe-Nolazco C, Quea-Vélez F, Morán-Mariños C, Pinedo-Torres I, Alva-Diaz C, Pacheco-Barrios K. Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis. PLoS One. 2021 May 13;16(5):e0251642. doi: 10.1371/journal.pone.0251642.
Oliveros-Lijap L, Ávila-Espinoza P, Ulloa V, Bernabe-Ortiz A. Calidad de vida en pacientes con neuropatía diabética periférica: estudio transversal en Lima, Perú. Acta Med Peru. 2018;35(3):160-167. ISSN 1728-5917.
Prado F. Neuropatía periférica y vitaminas del complejo B: revisión y algoritmo terapéutico. Rev Mex Endocrinol Metab Nutr. 2023;10:128-143. doi: 10.24875/RME.23000012.
Sathienluckana T, Palapinyo S, Yotsombut K, Wanothayaroj E, Sithinamsuwan P, Suksomboon N. Expert consensus guidelines for community pharmacists in the management of diabetic peripheral neuropathy with a combination of neurotropic B vitamins. J Pharm Policy Practiice 2024;17(1):2306866. doi: 10.1080/20523211.2024.2306866.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Revista de la Facultad de Medicina Humana
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
